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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 12 — Dec. 1, 2013
  • pp: 2781–2794

Fiber bundle endocytoscopy

Michael Hughes, Tou Pin Chang, and Guang-Zhong Yang  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 12, pp. 2781-2794 (2013)

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Endocytoscopy is an optical biopsy technique which uses a miniaturized camera to capture white light microscopy images through an endoscope. We have developed an alternative design that instead relays images to an external camera via a coherent fiber bundle. In this paper we characterize the device and demonstrate microscopy of porcine tissue ex vivo. One advantage of our approach is the ease with which other bundle-compatible imaging modalities can be deployed simultaneously. We show this by acquiring quasi-simultaneous endocytoscopy and fluorescence confocal endomicroscopy images through a single fiber bundle. This opens up possibilities for multi-modal endomicroscopy, combining white light and fluorescence imaging.

© 2013 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(170.2150) Medical optics and biotechnology : Endoscopic imaging

ToC Category:
Endoscopes, Catheters and Micro-Optics

Original Manuscript: July 26, 2013
Revised Manuscript: September 27, 2013
Manuscript Accepted: September 28, 2013
Published: November 11, 2013

Michael Hughes, Tou Pin Chang, and Guang-Zhong Yang, "Fiber bundle endocytoscopy," Biomed. Opt. Express 4, 2781-2794 (2013)

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