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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 12 — Dec. 1, 2013
  • pp: 2828–2834

Characterizing human pancreatic cancer precursor using quantitative tissue optical spectroscopy

Seung Yup Lee, William R. Lloyd, Malavika Chandra, Robert H. Wilson, Barbara McKenna, Diane Simeone, James Scheiman, and Mary-Ann Mycek  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 12, pp. 2828-2834 (2013)
http://dx.doi.org/10.1364/BOE.4.002828


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Abstract

In a pilot study, multimodal optical spectroscopy coupled with quantitative tissue-optics models distinguished intraductal papillary mucinous neoplasm (IPMN), a common precursor to pancreatic cancer, from normal tissues in freshly excised human pancreas. A photon-tissue interaction (PTI) model extracted parameters associated with cellular nuclear size and refractive index (from reflectance spectra) and extracellular collagen content (from fluorescence spectra). The results suggest that tissue optical spectroscopy has the potential to characterize pre-cancerous neoplasms in human pancreatic tissues.

© 2013 Optical Society of America

OCIS Codes
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Optics in Cancer Research

History
Original Manuscript: July 31, 2013
Revised Manuscript: September 29, 2013
Manuscript Accepted: October 31, 2013
Published: November 14, 2013

Citation
Seung Yup Lee, William R. Lloyd, Malavika Chandra, Robert H. Wilson, Barbara McKenna, Diane Simeone, James Scheiman, and Mary-Ann Mycek, "Characterizing human pancreatic cancer precursor using quantitative tissue optical spectroscopy," Biomed. Opt. Express 4, 2828-2834 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-12-2828


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