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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 12 — Dec. 1, 2013
  • pp: 2846–2854

Optical fine-needle imaging biopsy of the brain

Jun Ki Kim, Jin Woo Choi, and Seok H. Yun  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 12, pp. 2846-2854 (2013)
http://dx.doi.org/10.1364/BOE.4.002846


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Abstract

We demonstrate optical fine-needle imaging biopsy (FNIB), combining a fine needle (22 gauge) and a high-resolution side-view probe (350-μm diameter) for minimally invasive interrogation of brain tissue in situ. We apply this technique to examine pathogenesis in murine models of neurodegeneration, brain metastasis of melanoma, and arterial occlusion, respectively. The demonstrated ability to obtain cellular images in the deep brain without craniotomy may be useful in the longitudinal studies of brain diseases.

© 2013 Optical Society of America

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(180.1790) Microscopy : Confocal microscopy
(180.2520) Microscopy : Fluorescence microscopy

ToC Category:
Endoscopes, Catheters and Micro-Optics

History
Original Manuscript: September 5, 2013
Revised Manuscript: October 26, 2013
Manuscript Accepted: October 26, 2013
Published: November 15, 2013

Citation
Jun Ki Kim, Jin Woo Choi, and Seok H. Yun, "Optical fine-needle imaging biopsy of the brain," Biomed. Opt. Express 4, 2846-2854 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-12-2846


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References

  1. J. Tilgner, M. Herr, C. Ostertag, and B. Volk, “Validation of intraoperative diagnoses using smear preparations from stereotactic brain biopsies: intraoperative versus final diagnosis--influence of clinical factors,” Neurosurgery56(2), 257–265, discussion 257–265 (2005). [CrossRef] [PubMed]
  2. W. Feiden, U. Steude, K. Bise, and O. Gündisch, “Accuracy of stereotactic brain tumor biopsy: comparison of the histologic findings in biopsy cylinders and resected tumor tissue,” Neurosurg. Rev.14(1), 51–56 (1991). [PubMed]
  3. F. Helmchen and W. Denk, “Deep tissue two-photon microscopy,” Nat. Methods2(12), 932–940 (2005). [CrossRef] [PubMed]
  4. A. Holtmaat, T. Bonhoeffer, D. K. Chow, J. Chuckowree, V. De Paola, S. B. Hofer, M. Hübener, T. Keck, G. Knott, W. C. Lee, R. Mostany, T. D. Mrsic-Flogel, E. Nedivi, C. Portera-Cailliau, K. Svoboda, J. T. Trachtenberg, and L. Wilbrecht, “Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window,” Nat. Protoc.4(8), 1128–1144 (2009). [CrossRef] [PubMed]
  5. G. Yang, F. Pan, C. N. Parkhurst, J. Grutzendler, and W. B. Gan, “Thinned-skull cranial window technique for long-term imaging of the cortex in live mice,” Nat. Protoc.5(2), 201–208 (2010). [CrossRef] [PubMed]
  6. R. P. J. Barretto, T. H. Ko, J. C. Jung, T. J. Wang, G. Capps, A. C. Waters, Y. Ziv, A. Attardo, L. Recht, and M. J. Schnitzer, “Time-lapse imaging of disease progression in deep brain areas using fluorescence microendoscopy,” Nat. Med.17(2), 223–228 (2011). [CrossRef] [PubMed]
  7. L. Fu, A. Jain, C. Cranfield, H. K. Xie, and M. Gu, “Three-dimensional nonlinear optical endoscopy,” J. Biomed. Opt.12(4), 040501 (2007). [CrossRef] [PubMed]
  8. J. K. Kim, W. M. Lee, P. Kim, M. Choi, K. Jung, S. Kim, and S. H. Yun, “Fabrication and operation of GRIN probes for in vivo fluorescence cellular imaging of internal organs in small animals,” Nat. Protoc.7(8), 1456–1469 (2012). [CrossRef] [PubMed]
  9. J. K. Kim J. W. Choi and S. H. Yun, “350 μm sideview optical probe for imaging the murine brain in vivo from the cortex to the hypothalamus,” J. Biomed. Opt.18, 050502 (2013). [CrossRef]
  10. P. Kim, M. Puoris’haag, D. Côté, C. P. Lin, and S. H. Yun, “In vivo confocal and multiphoton microendoscopy,” J. Biomed. Opt.13(1), 010501 (2008). [CrossRef] [PubMed]
  11. K. Nagashima, Y. Fujii, T. Tsukamoto, S. Nukuzuma, M. Satoh, M. Fujita, Y. Fujioka, and H. Akagi, “Apoptotic process of cerebellar degeneration in experimental methylmercury intoxication of rats,” Acta Neuropathol.91(1), 72–77 (1995). [CrossRef] [PubMed]
  12. A. Hara, M. Niwa, N. Yoshimi, and H. Mori, “Apoptotic cell death in vulnerable subpopulation of cerebellar granule cells,” Acta Neuropathol.94(5), 517–518 (1997). [CrossRef] [PubMed]
  13. L. Beni-Adani, I. Gozes, Y. Cohen, Y. Assaf, R. A. Steingart, D. E. Brenneman, O. Eizenberg, V. Trembolver, and E. Shohami, “A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice,” J. Pharmacol. Exp. Ther.296(1), 57–63 (2001). [PubMed]
  14. T. V. Arumugam, S. L. Chan, D. G. Jo, G. Yilmaz, S. C. Tang, A. Cheng, M. Gleichmann, E. Okun, V. D. Dixit, S. Chigurupati, M. R. Mughal, X. Ouyang, L. Miele, T. Magnus, S. Poosala, D. N. Granger, and M. P. Mattson, “Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke,” Nat. Med.12(6), 621–623 (2006). [CrossRef] [PubMed]
  15. G. Stoll, C. Kleinschnitz, and B. Nieswandt, “Combating innate inflammation: a new paradigm for acute treatment of stroke?” Ann. N. Y. Acad. Sci.1207(1), 149–154 (2010). [CrossRef] [PubMed]
  16. R. Jin, G. Yang, and G. Li, “Inflammatory mechanisms in ischemic stroke: role of inflammatory cells,” J. Leukoc. Biol.87(5), 779–789 (2010). [CrossRef] [PubMed]
  17. A. F. Eichler, E. Chung, D. P. Kodack, J. S. Loeffler, D. Fukumura, and R. K. Jain, “The biology of brain metastases-translation to new therapies,” Nat Rev Clin Oncol8(6), 344–356 (2011). [PubMed]
  18. Y. Chudnovsky, P. A. Khavari, and A. E. Adams, “Melanoma genetics and the development of rational therapeutics,” J. Clin. Invest.115(4), 813–824 (2005). [PubMed]
  19. T. H. Chia and M. J. Levene, “Microprisms for in vivo multilayer cortical imaging,” J. Neurophysiol.102(2), 1310–1314 (2009). [CrossRef] [PubMed]
  20. D. E. Bredesen, R. V. Rao, and P. Mehlen, “Cell death in the nervous system,” Nature443(7113), 796–802 (2006). [CrossRef] [PubMed]
  21. K. Saijo, B. Winner, C. T. Carson, J. G. Collier, L. Boyer, M. G. Rosenfeld, F. H. Gage, and C. K. Glass, “A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death,” Cell137(1), 47–59 (2009). [CrossRef] [PubMed]
  22. M. Fuhrmann, T. Bittner, C. K. E. Jung, S. Burgold, R. M. Page, G. Mitteregger, C. Haass, F. M. LaFerla, H. Kretzschmar, and J. Herms, “Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer’s disease,” Nat. Neurosci.13(4), 411–413 (2010). [CrossRef] [PubMed]
  23. M. Gelderblom, F. Leypoldt, K. Steinbach, D. Behrens, C. U. Choe, D. A. Siler, T. V. Arumugam, E. Orthey, C. Gerloff, E. Tolosa, and T. Magnus, “Temporal and spatial dynamics of cerebral immune cell accumulation in stroke,” Stroke40(5), 1849–1857 (2009). [CrossRef] [PubMed]
  24. E. Storkebaum, A. Quaegebeur, M. Vikkula, and P. Carmeliet, “Cerebrovascular disorders: molecular insights and therapeutic opportunities,” Nat. Neurosci.14(11), 1390–1397 (2011). [CrossRef] [PubMed]
  25. I. J. Fidler, G. Schackert, R. D. Zhang, R. Radinsky, and T. Fujimaki, “The biology of melanoma brain metastasis,” Cancer Metastasis Rev.18(3), 387–400 (1999). [CrossRef] [PubMed]
  26. R. P. Barretto, B. Messerschmidt, and M. J. Schnitzer, “In vivo fluorescence imaging with high-resolution microlenses,” Nat. Methods6(7), 511–512 (2009). [CrossRef] [PubMed]
  27. W. M. Lee and S. H. Yun, “Adaptive aberration correction of GRIN lenses for confocal endomicroscopy,” Opt. Lett.36(23), 4608–4610 (2011). [CrossRef] [PubMed]
  28. F. Zhang, V. Gradinaru, A. R. Adamantidis, R. Durand, R. D. Airan, L. de Lecea, and K. Deisseroth, “Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures,” Nat. Protoc.5(3), 439–456 (2010). [CrossRef] [PubMed]

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