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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 12 — Dec. 1, 2013
  • pp: 2846–2854

Optical fine-needle imaging biopsy of the brain

Jun Ki Kim, Jin Woo Choi, and Seok H. Yun  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 12, pp. 2846-2854 (2013)

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We demonstrate optical fine-needle imaging biopsy (FNIB), combining a fine needle (22 gauge) and a high-resolution side-view probe (350-μm diameter) for minimally invasive interrogation of brain tissue in situ. We apply this technique to examine pathogenesis in murine models of neurodegeneration, brain metastasis of melanoma, and arterial occlusion, respectively. The demonstrated ability to obtain cellular images in the deep brain without craniotomy may be useful in the longitudinal studies of brain diseases.

© 2013 Optical Society of America

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(180.1790) Microscopy : Confocal microscopy
(180.2520) Microscopy : Fluorescence microscopy

ToC Category:
Endoscopes, Catheters and Micro-Optics

Original Manuscript: September 5, 2013
Revised Manuscript: October 26, 2013
Manuscript Accepted: October 26, 2013
Published: November 15, 2013

Jun Ki Kim, Jin Woo Choi, and Seok H. Yun, "Optical fine-needle imaging biopsy of the brain," Biomed. Opt. Express 4, 2846-2854 (2013)

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