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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 12 — Dec. 1, 2013
  • pp: 2938–2944

Single snapshot imaging of optical properties

Jean Vervandier and Sylvain Gioux  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 12, pp. 2938-2944 (2013)

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A novel acquisition and processing method that enables single snapshot wide field imaging of optical properties in the Spatial Frequency Domain (SFD) is described. This method makes use of a Fourier transform performed on a single image and processing in the frequency space to extract two spatial frequency images at once. The performance of the method is compared to the standard six image SFD acquisition method, assessed on tissue mimicking phantoms and in vivo. Overall both methods perform similarly in extracting optical properties.

© 2013 Optical Society of America

OCIS Codes
(110.2960) Imaging systems : Image analysis
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Diffuse Optical Imaging

Original Manuscript: September 6, 2013
Revised Manuscript: October 9, 2013
Manuscript Accepted: October 15, 2013
Published: November 22, 2013

Jean Vervandier and Sylvain Gioux, "Single snapshot imaging of optical properties," Biomed. Opt. Express 4, 2938-2944 (2013)

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  1. S. Gioux, H. S. Choi, and J. V. Frangioni, “Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation,” Mol. Imaging9(5), 237–255 (2010). [PubMed]
  2. G. M. van Dam, G. Themelis, L. M. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. Arts, A. G. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results,” Nat. Med.17(10), 1315–1319 (2011). [CrossRef] [PubMed]
  3. E. M. Sevick-Muraca, “Translation of near-infrared fluorescence imaging technologies: emerging clinical applications,” Annu. Rev. Med.63(1), 217–231 (2012). [CrossRef] [PubMed]
  4. T. D. O’Sullivan, A. Leproux, J. H. Chen, S. Bahri, A. Matlock, D. Roblyer, C. E. McLaren, W. P. Chen, A. E. Cerussi, M. Y. Su, and B. J. Tromberg, “Optical imaging correlates with magnetic resonance imaging breast density and reveals composition changes during neoadjuvant chemotherapy,” Breast Cancer Res.15(1), R14 (2013). [CrossRef] [PubMed]
  5. A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, D. J. Cuccia, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “Spectral discrimination of breast pathologies in situ using spatial frequency domain imaging,” Breast Cancer Res.15(4), R61 (2013). [CrossRef] [PubMed]
  6. J. Q. Brown, T. M. Bydlon, S. A. Kennedy, M. L. Caldwell, J. E. Gallagher, M. Junker, L. G. Wilke, W. T. Barry, J. Geradts, and N. Ramanujam, “Optical spectral surveillance of breast tissue landscapes for detection of residual disease in breast tumor margins,” PLoS ONE8(7), e69906 (2013). [CrossRef] [PubMed]
  7. S. Hariri Tabrizi, S. Mahmoud Reza Aghamiri, F. Farzaneh, A. Amelink, and H. J. Sterenborg, “Single fiber reflectance spectroscopy on cervical premalignancies: the potential for reduction of the number of unnecessary biopsies,” J. Biomed. Opt.18(1), 017002 (2013). [CrossRef] [PubMed]
  8. O. M. A’Amar, L. Liou, E. Rodriguez-Diaz, A. De Las Morenas, and I. J. Bigio, “Comparison of elastic scattering spectroscopy with histology in ex vivo prostate glands: potential application for optically guided biopsy and directed treatment,” Lasers Med. Sci.28(5), 1323–1329 (2013). [CrossRef] [PubMed]
  9. D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt.14(2), 024012 (2009). [CrossRef] [PubMed]
  10. N. Dognitz and G. Wagnieres, “Determination of tissue optical properties by steady-state spatial frequency-domain reflectometry,” Lasers Med. Sci.13, 55–65 (1998). [CrossRef]
  11. S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt.16(8), 086015 (2011). [CrossRef] [PubMed]
  12. F. Ayers, A. Grant, D. Kuo, D. J. Cuccia, and A. J. Durkin, “Fabrication and characterization of silicone-based tissue phantoms with tunable optical properties in the visible and near infrared domain,” in Proc. SPIE(2008), p. 6870E.
  13. J. Q. Nguyen, R. B. Saager, D. J. Cuccia, K. M. Kelly, J. Jakowatz, D. Hsiang, and A. J. Durkin, “Effects of motion on optical properties in the spatial frequency domain,” J. Biomed. Opt.16(12), 126009 (2011). [CrossRef] [PubMed]
  14. S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt.14(3), 034045 (2009). [CrossRef] [PubMed]

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