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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 5 — May. 1, 2013
  • pp: 741–759

A GAMOS plug-in for GEANT4 based Monte Carlo simulation of radiation-induced light transport in biological media

Adam K. Glaser, Stephen C. Kanick, Rongxiao Zhang, Pedro Arce, and Brian W. Pogue  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 5, pp. 741-759 (2013)
http://dx.doi.org/10.1364/BOE.4.000741


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Abstract

We describe a tissue optics plug-in that interfaces with the GEANT4/GAMOS Monte Carlo (MC) architecture, providing a means of simulating radiation-induced light transport in biological media for the first time. Specifically, we focus on the simulation of light transport due to the Čerenkov effect (light emission from charged particle’s traveling faster than the local speed of light in a given medium), a phenomenon which requires accurate modeling of both the high energy particle and subsequent optical photon transport, a dynamic coupled process that is not well-described by any current MC framework. The results of validation simulations show excellent agreement with currently employed biomedical optics MC codes, [i.e., Monte Carlo for Multi-Layered media (MCML), Mesh-based Monte Carlo (MMC), and diffusion theory], and examples relevant to recent studies into detection of Čerenkov light from an external radiation beam or radionuclide are presented. While the work presented within this paper focuses on radiation-induced light transport, the core features and robust flexibility of the plug-in modified package make it also extensible to more conventional biomedical optics simulations. The plug-in, user guide, example files, as well as the necessary files to reproduce the validation simulations described within this paper are available online at http://www.dartmouth.edu/optmed/research-projects/monte-carlo-software .

© 2013 OSA

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5280) Medical optics and biotechnology : Photon migration
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Optics of Tissue and Turbid Media

History
Original Manuscript: February 5, 2013
Revised Manuscript: April 3, 2013
Manuscript Accepted: April 9, 2013
Published: April 17, 2013

Virtual Issues
May 7, 2013 Spotlight on Optics

Citation
Adam K. Glaser, Stephen C. Kanick, Rongxiao Zhang, Pedro Arce, and Brian W. Pogue, "A GAMOS plug-in for GEANT4 based Monte Carlo simulation of radiation-induced light transport in biological media," Biomed. Opt. Express 4, 741-759 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-5-741


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