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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 6 — Jun. 1, 2013
  • pp: 789–802

Discussion on the validity of NIR spectral data in non-invasive blood glucose sensing

Wanjie Zhang, Rong Liu, Wen Zhang, Hao Jia, and Kexin Xu  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 6, pp. 789-802 (2013)

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In this paper, the effects of two-dimensional correlation spectroscopy (2DCOS) on chance correlations in the spectral data, generated from the correlations between glucose concentration and some undesirable experimental factors, such as instrument drift, sample temperature variations, and interferent compositions in the sample matrix, are investigated. The aim is to evaluate the validity of the spectral data set, instead of assessing the calibration models, and then to provide a complementary procedure for better verifying or rejecting the data set. It includes tracing back to the source of the chance correlation on the chemical basis, selecting appropriate preprocessing methods before building multivariate calibration models, and therefore may avoid invalid models. The utility of the proposed analysis is demonstrated with a series of aqueous solutions using near-infrared spectra over the overtone band of glucose. Results show that, spectral variations from chance correlations induced by those experimental factors can be determined by the 2DCOS method, which develops avenues for prospectively accurate prediction in clinical application of this technology.

© 2013 OSA

OCIS Codes
(070.4790) Fourier optics and signal processing : Spectrum analysis
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(300.6340) Spectroscopy : Spectroscopy, infrared

ToC Category:
Spectroscopic Diagnostics

Original Manuscript: March 13, 2013
Revised Manuscript: April 26, 2013
Manuscript Accepted: April 26, 2013
Published: May 7, 2013

Wanjie Zhang, Rong Liu, Wen Zhang, Hao Jia, and Kexin Xu, "Discussion on the validity of NIR spectral data in non-invasive blood glucose sensing," Biomed. Opt. Express 4, 789-802 (2013)

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