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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 6 — Jun. 1, 2013
  • pp: 900–908

Characterization and treatment monitoring of inflammatory arthritis by photoacoustic imaging: a study on adjuvant-induced arthritis rat model

Justin R. Rajian, Xia Shao, David L. Chamberland, and Xueding Wang  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 6, pp. 900-908 (2013)

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Neovascularity also known as angiogenesis is an early feature of inflammatory arthritis disease. Therefore, identifying the development of neovascularity is one way to potentially detect and characterize arthritis. Laser-based photoacoustic imaging (PAI) is an emerging biomedical imaging modality which may aid in the detection of both early and continued development of neovascularity. In this work, we investigated the feasibility of PAI to measure angiogenesis, for the purpose of evaluating and monitoring inflammatory arthritis and responses to treatment. The imaging results on an arthritis rat model demonstrate that 1) there is noticeable enhancement in image intensities in the arthritic ankle joints when compared to the normal joints, and 2) there is noticeable decrease in image intensities in the arthritic ankle joints after treatment when compared to the untreated arthritic joints. In order to validate the findings from PAI, we performed positron emission tomography (PET) and histology on the same joints. The diameters of the ankle joints, as a clinical score of the arthritis, were also measured at each time point.

© 2013 OSA

OCIS Codes
(110.7170) Imaging systems : Ultrasound
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Photoacoustic Imaging and Spectroscopy

Original Manuscript: March 4, 2013
Revised Manuscript: April 22, 2013
Manuscript Accepted: May 7, 2013
Published: May 17, 2013

Justin R. Rajian, Xia Shao, David L. Chamberland, and Xueding Wang, "Characterization and treatment monitoring of inflammatory arthritis by photoacoustic imaging: a study on adjuvant-induced arthritis rat model," Biomed. Opt. Express 4, 900-908 (2013)

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