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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 6 — Jun. 1, 2013
  • pp: 938–949

Multimodal snapshot spectral imaging for oral cancer diagnostics: a pilot study

Noah Bedard, Richard A. Schwarz, Aaron Hu, Vijayashree Bhattar, Jana Howe, Michelle D. Williams, Ann M. Gillenwater, Rebecca Richards-Kortum, and Tomasz S. Tkaczyk  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 6, pp. 938-949 (2013)
http://dx.doi.org/10.1364/BOE.4.000938


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Abstract

Optical imaging and spectroscopy have emerged as effective tools for detecting malignant changes associated with oral cancer. While clinical studies have demonstrated high sensitivity and specificity for detection, current devices either interrogate a small region or can have reduced performance for some benign lesions. We describe a snapshot imaging spectrometer that combines the large field-of-view of widefield imaging with the diagnostic strength of spectroscopy. The portable device can stream RGB images at 7.2 frames per second and record both autofluorescence and reflectance spectral datacubes in < 1 second. We report initial data from normal volunteers and oral cancer patients.

© 2013 OSA

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(110.4234) Imaging systems : Multispectral and hyperspectral imaging

ToC Category:
Multimodal Imaging

History
Original Manuscript: April 4, 2013
Revised Manuscript: May 22, 2013
Manuscript Accepted: May 22, 2013
Published: May 24, 2013

Citation
Noah Bedard, Richard A. Schwarz, Aaron Hu, Vijayashree Bhattar, Jana Howe, Michelle D. Williams, Ann M. Gillenwater, Rebecca Richards-Kortum, and Tomasz S. Tkaczyk, "Multimodal snapshot spectral imaging for oral cancer diagnostics: a pilot study," Biomed. Opt. Express 4, 938-949 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-6-938


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