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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 7 — Jul. 1, 2013
  • pp: 1051–1060

A method for detecting forward scattering signals on-chip with a photonic-microfluidic integrated device

Benjamin R. Watts, Zhiyi Zhang, Chang-Qing Xu, Xudong Cao, and Min Lin  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 7, pp. 1051-1060 (2013)
http://dx.doi.org/10.1364/BOE.4.001051


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Abstract

A photonic integrated microfluidic device is demonstrated to perform optical excitation and forward scatter collection all on-chip in a planar format. Integrated on-chip optics formed a tailored beam geometry for optimal excitation of particles while a special design modification allowed for on-chip forward collection with the beam shaping capabilities. A notch was placed in the lens system that caused a dark spot on the facet of a collection waveguide while not affecting the beam geometry at the point of interrogation. The modified device with the ability to form a 10 μm beam geometry was demonstrated to detect the forward scatter from blank 5 μm diameter polystyrene beads. Free-space collection of side scatter signals was performed simultaneously with the on-chip collection and the designs demonstrated and enhanced SNR while the reliability of detection was determined to be appropriate for many applications. Excellent performance was confirmed via a false positive rate of 0.4%, a missed events rate of 6.8%, and a coincident rate of 96.3% as determined between simultaneously performed free-space and on-chip detection schemes.

© 2013 OSA

OCIS Codes
(130.3120) Integrated optics : Integrated optics devices
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(230.3990) Optical devices : Micro-optical devices
(290.2558) Scattering : Forward scattering
(130.5460) Integrated optics : Polymer waveguides

ToC Category:
Microfluidics

History
Original Manuscript: January 23, 2013
Revised Manuscript: March 19, 2013
Manuscript Accepted: April 16, 2013
Published: June 7, 2013

Citation
Benjamin R. Watts, Zhiyi Zhang, Chang-Qing Xu, Xudong Cao, and Min Lin, "A method for detecting forward scattering signals on-chip with a photonic-microfluidic integrated device," Biomed. Opt. Express 4, 1051-1060 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-7-1051


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