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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 7 — Jul. 1, 2013
  • pp: 1153–1165

3D modeling to characterize lamina cribrosa surface and pore geometries using in vivo images from normal and glaucomatous eyes

Nripun Sredar, Kevin M. Ivers, Hope M. Queener, George Zouridakis, and Jason Porter  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 7, pp. 1153-1165 (2013)
http://dx.doi.org/10.1364/BOE.4.001153


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Abstract

En face adaptive optics scanning laser ophthalmoscope (AOSLO) images of the anterior lamina cribrosa surface (ALCS) represent a 2D projected view of a 3D laminar surface. Using spectral domain optical coherence tomography images acquired in living monkey eyes, a thin plate spline was used to model the ALCS in 3D. The 2D AOSLO images were registered and projected onto the 3D surface that was then tessellated into a triangular mesh to characterize differences in pore geometry between 2D and 3D images. Following 3D transformation of the anterior laminar surface in 11 normal eyes, mean pore area increased by 5.1 ± 2.0% with a minimal change in pore elongation (mean change = 0.0 ± 0.2%). These small changes were due to the relatively flat laminar surfaces inherent in normal eyes (mean radius of curvature = 3.0 ± 0.5 mm). The mean increase in pore area was larger following 3D transformation in 4 glaucomatous eyes (16.2 ± 6.0%) due to their more steeply curved laminar surfaces (mean radius of curvature = 1.3 ± 0.1 mm), while the change in pore elongation was comparable to that in normal eyes (−0.2 ± 2.0%). This 3D transformation and tessellation method can be used to better characterize and track 3D changes in laminar pore and surface geometries in glaucoma.

© 2013 OSA

OCIS Codes
(000.3860) General : Mathematical methods in physics
(330.4460) Vision, color, and visual optics : Ophthalmic optics and devices
(110.1080) Imaging systems : Active or adaptive optics

ToC Category:
Ophthalmology Applications

History
Original Manuscript: April 8, 2013
Revised Manuscript: June 6, 2013
Manuscript Accepted: June 7, 2013
Published: June 14, 2013

Citation
Nripun Sredar, Kevin M. Ivers, Hope M. Queener, George Zouridakis, and Jason Porter, "3D modeling to characterize lamina cribrosa surface and pore geometries using in vivo images from normal and glaucomatous eyes," Biomed. Opt. Express 4, 1153-1165 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-7-1153


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