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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 7 — Jul. 1, 2013
  • pp: 978–994

Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions

Rickson C. Mesquita, Steven S. Schenkel, David L. Minkoff, Xiangping Lu, Christopher G. Favilla, Patrick M. Vora, David R. Busch, Malavika Chandra, Joel H. Greenberg, John A. Detre, and A. G. Yodh  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 7, pp. 978-994 (2013)

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A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation tasks, both with and without pressure. Baseline (resting) data enabled estimation of extra-cerebral flow signals and their pressure dependencies. A simple two-component model was used to derive baseline and activated cerebral blood flow (CBF) signals, and the DCS flow indices were also cross-correlated with concurrent Transcranial Doppler Ultrasound (TCD) blood velocity measurements. The study suggests new pressure-dependent experimental paradigms for elucidation of blood flow contributions from extra-cerebral and cerebral tissues.

© 2013 OSA

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

ToC Category:
Optics of Tissue and Turbid Media

Original Manuscript: March 22, 2013
Revised Manuscript: May 13, 2013
Manuscript Accepted: May 14, 2013
Published: June 3, 2013

Rickson C. Mesquita, Steven S. Schenkel, David L. Minkoff, Xiangping Lu, Christopher G. Favilla, Patrick M. Vora, David R. Busch, Malavika Chandra, Joel H. Greenberg, John A. Detre, and A. G. Yodh, "Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions," Biomed. Opt. Express 4, 978-994 (2013)

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