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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 8 — Aug. 1, 2013
  • pp: 1351–1365

Time-resolved diffuse optical tomography using fast-gated single-photon avalanche diodes

Agathe Puszka, Laura Di Sieno, Alberto Dalla Mora, Antonio Pifferi, Davide Contini, Gianluca Boso, Alberto Tosi, Lionel Hervé, Anne Planat-Chrétien, Anne Koenig, and Jean-Marc Dinten  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 8, pp. 1351-1365 (2013)
http://dx.doi.org/10.1364/BOE.4.001351


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Abstract

We present the first experimental results of reflectance Diffuse Optical Tomography (DOT) performed with a fast-gated single-photon avalanche diode (SPAD) coupled to a time-correlated single-photon counting system. The Mellin-Laplace transform was employed to process time-resolved data. We compare the performances of the SPAD operated in the gated mode vs. the non-gated mode for the detection and localization of an absorbing inclusion deeply embedded in a turbid medium for 5 and 15 mm interfiber distances. We demonstrate that, for a given acquisition time, the gated mode enables the detection and better localization of deeper absorbing inclusions than the non-gated mode. These results obtained on phantoms demonstrate the efficacy of time-resolved DOT at small interfiber distances. By achieving depth sensitivity with limited acquisition times, the gated mode increases the relevance of reflectance DOT at small interfiber distance for clinical applications.

© 2013 OSA

OCIS Codes
(030.5260) Coherence and statistical optics : Photon counting
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.6960) Medical optics and biotechnology : Tomography
(170.7050) Medical optics and biotechnology : Turbid media
(230.5170) Optical devices : Photodiodes

ToC Category:
Diffuse Optical Imaging

History
Original Manuscript: May 7, 2013
Revised Manuscript: June 28, 2013
Manuscript Accepted: June 28, 2013
Published: July 17, 2013

Citation
Agathe Puszka, Laura Di Sieno, Alberto Dalla Mora, Antonio Pifferi, Davide Contini, Gianluca Boso, Alberto Tosi, Lionel Hervé, Anne Planat-Chrétien, Anne Koenig, and Jean-Marc Dinten, "Time-resolved diffuse optical tomography using fast-gated single-photon avalanche diodes," Biomed. Opt. Express 4, 1351-1365 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-8-1351


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