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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 9 — Sep. 1, 2013
  • pp: 1559–1570

An optical system for detecting 3D high-speed oscillation of a single ultrasound microbubble

Yuan Liu and Baohong Yuan  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 9, pp. 1559-1570 (2013)
http://dx.doi.org/10.1364/BOE.4.001559


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Abstract

As contrast agents, microbubbles have been playing significant roles in ultrasound imaging. Investigation of microbubble oscillation is crucial for microbubble characterization and detection. Unfortunately, 3-dimensional (3D) observation of microbubble oscillation is challenging and costly because of the bubble size—a few microns in diameter—and the high-speed dynamics under MHz ultrasound pressure waves. In this study, a cost-efficient optical confocal microscopic system combined with a gated and intensified charge-coupled device (ICCD) camera were developed to detect 3D microbubble oscillation. The capability of imaging microbubble high-speed oscillation with much lower costs than with an ultra-fast framing or streak camera system was demonstrated. In addition, microbubble oscillations along both lateral (x and y) and axial (z) directions were demonstrated. Accordingly, this system is an excellent alternative for 3D investigation of microbubble high-speed oscillation, especially when budgets are limited.

© 2013 OSA

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.1790) Medical optics and biotechnology : Confocal microscopy
(170.7160) Medical optics and biotechnology : Ultrafast technology
(170.7170) Medical optics and biotechnology : Ultrasound

ToC Category:
Microscopy

History
Original Manuscript: June 25, 2013
Revised Manuscript: July 31, 2013
Manuscript Accepted: July 31, 2013
Published: August 8, 2013

Virtual Issues
Bio-Optics: Design and Applications (2013) Biomedical Optics Express

Citation
Yuan Liu and Baohong Yuan, "An optical system for detecting 3D high-speed oscillation of a single ultrasound microbubble," Biomed. Opt. Express 4, 1559-1570 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-9-1559


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