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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 9 — Sep. 1, 2013
  • pp: 1595–1609

Static and dynamic crystalline lens accommodation evaluated using quantitative 3-D OCT

Enrique Gambra, Sergio Ortiz, Pablo Perez-Merino, Michalina Gora, Maciej Wojtkowski, and Susana Marcos  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 9, pp. 1595-1609 (2013)
http://dx.doi.org/10.1364/BOE.4.001595


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Abstract

Custom high-resolution high-speed anterior segment spectral domain Optical Coherence Tomography (OCT) provided with automatic quantification and distortion correction algorithms was used to characterize three-dimensionally (3-D) the human crystalline lens in vivo in four subjects, for accommodative demands between 0 to 6 D in 1 D steps. Anterior and posterior lens radii of curvature decreased with accommodative demand at rates of 0.73 and 0.20 mm/D, resulting in an increase of the estimated optical power of the eye of 0.62 D per diopter of accommodative demand. Dynamic fluctuations in crystalline lens radii of curvature, anterior chamber depth and lens thickness were also estimated from dynamic 2-D OCT images (14 Hz), acquired during 5-s of steady fixation, for different accommodative demands. Estimates of the eye power from dynamical geometrical measurements revealed an increase of the fluctuations of the accommodative response from 0.07 D to 0.47 D between 0 and 6 D (0.044 D per D of accommodative demand). A sensitivity analysis showed that the fluctuations of accommodation were driven by dynamic changes in the lens surfaces, particularly in the posterior lens surface.

© 2013 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(110.6880) Imaging systems : Three-dimensional image acquisition
(120.4640) Instrumentation, measurement, and metrology : Optical instruments
(120.6650) Instrumentation, measurement, and metrology : Surface measurements, figure
(330.7322) Vision, color, and visual optics : Visual optics, accommodation
(330.7327) Vision, color, and visual optics : Visual optics, ophthalmic instrumentation

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: May 29, 2013
Revised Manuscript: July 21, 2013
Manuscript Accepted: July 21, 2013
Published: August 8, 2013

Citation
Enrique Gambra, Sergio Ortiz, Pablo Perez-Merino, Michalina Gora, Maciej Wojtkowski, and Susana Marcos, "Static and dynamic crystalline lens accommodation evaluated using quantitative 3-D OCT," Biomed. Opt. Express 4, 1595-1609 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-9-1595


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