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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 9 — Sep. 1, 2013
  • pp: 1683–1691

Dark-field circular depolarization optical coherence microscopy

Kalpesh Mehta, Pengfei Zhang, Eugenia Li Ling Yeo, James Chen Yong Kah, and Nanguang Chen  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 9, pp. 1683-1691 (2013)

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Optical coherence microscopy (OCM) is a widely used structural imaging modality. To extend its application in molecular imaging, gold nanorods are widely used as contrast agents for OCM. However, they very often offer limited sensitivity as a result of poor signal to background ratio. Here we experimentally demonstrate that a novel OCM implementation based on dark-field circular depolarization detection can efficiently detect circularly depolarized signal from gold nanorods and at the same time efficiently suppress the background signals. This results into a significant improvement in signal to background ratio.

© 2013 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.5820) Instrumentation, measurement, and metrology : Scattering measurements
(180.3170) Microscopy : Interference microscopy
(290.5850) Scattering : Scattering, particles
(290.5855) Scattering : Scattering, polarization

ToC Category:
Optical Coherence Tomography

Original Manuscript: June 17, 2013
Revised Manuscript: August 6, 2013
Manuscript Accepted: August 8, 2013
Published: August 19, 2013

Virtual Issues
Novel Techniques in Microscopy (2013) Biomedical Optics Express

Kalpesh Mehta, Pengfei Zhang, Eugenia Li Ling Yeo, James Chen Yong Kah, and Nanguang Chen, "Dark-field circular depolarization optical coherence microscopy," Biomed. Opt. Express 4, 1683-1691 (2013)

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