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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 9 — Sep. 1, 2013
  • pp: 1724–1741

Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques

Hussain Fatakdawala, Shannon Poti, Feifei Zhou, Yang Sun, Julien Bec, Jing Liu, Diego R. Yankelevich, Steven P. Tinling, Regina F. Gandour-Edwards, D. Gregory Farwell, and Laura Marcu  »View Author Affiliations


Biomedical Optics Express, Vol. 4, Issue 9, pp. 1724-1741 (2013)
http://dx.doi.org/10.1364/BOE.4.001724


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Abstract

This work reports a multimodal system for label-free tissue diagnosis combining fluorescence lifetime imaging (FLIm), ultrasound backscatter microscopy (UBM), and photoacoustic imaging (PAI). This system provides complementary biochemical, structural and functional features allowing for enhanced in vivo detection of oral carcinoma. Results from a hamster oral carcinoma model (normal, precancer and carcinoma) are presented demonstrating the ability of FLIm to delineate biochemical composition at the tissue surface, UBM and related radiofrequency parameters to identify disruptions in the tissue microarchitecture and PAI to map optical absorption associated with specific tissue morphology and physiology.

© 2013 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.7180) Medical optics and biotechnology : Ultrasound diagnostics
(300.6500) Spectroscopy : Spectroscopy, time-resolved

ToC Category:
Multimodal Imaging

History
Original Manuscript: July 1, 2013
Revised Manuscript: August 9, 2013
Manuscript Accepted: August 9, 2013
Published: August 26, 2013

Virtual Issues
Bio-Optics: Design and Applications (2013) Biomedical Optics Express

Citation
Hussain Fatakdawala, Shannon Poti, Feifei Zhou, Yang Sun, Julien Bec, Jing Liu, Diego R. Yankelevich, Steven P. Tinling, Regina F. Gandour-Edwards, D. Gregory Farwell, and Laura Marcu, "Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques," Biomed. Opt. Express 4, 1724-1741 (2013)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-4-9-1724


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