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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 4, Iss. 9 — Sep. 1, 2013
  • pp: 1769–1785

Stochastic speckle noise compensation in optical coherence tomography using non-stationary spline-based speckle noise modelling

Andrew Cameron, Dorothy Lui, Ameneh Boroomand, Jeffrey Glaister, Alexander Wong, and Kostadinka Bizheva  »View Author Affiliations

Biomedical Optics Express, Vol. 4, Issue 9, pp. 1769-1785 (2013)

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Optical coherence tomography (OCT) allows for non-invasive 3D visualization of biological tissue at cellular level resolution. Often hindered by speckle noise, the visualization of important biological tissue details in OCT that can aid disease diagnosis can be improved by speckle noise compensation. A challenge with handling speckle noise is its inherent non-stationary nature, where the underlying noise characteristics vary with the spatial location. In this study, an innovative speckle noise compensation method is presented for handling the non-stationary traits of speckle noise in OCT imagery. The proposed approach centers on a non-stationary spline-based speckle noise modeling strategy to characterize the speckle noise. The novel method was applied to ultra high-resolution OCT (UHROCT) images of the human retina and corneo-scleral limbus acquired in-vivo that vary in tissue structure and optical properties. Test results showed improved performance of the proposed novel algorithm compared to a number of previously published speckle noise compensation approaches in terms of higher signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and better overall visual assessment.

© 2013 OSA

OCIS Codes
(030.6140) Coherence and statistical optics : Speckle
(100.2980) Image processing : Image enhancement
(100.3010) Image processing : Image reconstruction techniques
(110.4500) Imaging systems : Optical coherence tomography
(170.4460) Medical optics and biotechnology : Ophthalmic optics and devices

ToC Category:
Optical Coherence Tomography

Original Manuscript: May 24, 2013
Revised Manuscript: July 19, 2013
Manuscript Accepted: July 19, 2013
Published: August 28, 2013

Andrew Cameron, Dorothy Lui, Ameneh Boroomand, Jeffrey Glaister, Alexander Wong, and Kostadinka Bizheva, "Stochastic speckle noise compensation in optical coherence tomography using non-stationary spline-based speckle noise modelling," Biomed. Opt. Express 4, 1769-1785 (2013)

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