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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 1 — Jan. 1, 2014
  • pp: 167–182

Dual-band Fourier domain optical coherence tomography with depth-related compensations

Miao Zhang, Lixin Ma, and Ping Yu  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 1, pp. 167-182 (2014)
http://dx.doi.org/10.1364/BOE.5.000167


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Abstract

Dual-band Fourier domain optical coherence tomography (FD-OCT) provides depth-resolved spectroscopic imaging that enhances tissue contrast and reduces image speckle. However, previous dual-band FD-OCT systems could not correctly give the tissue spectroscopic contrast due to depth-related discrepancy in the imaging method and attenuation in biological tissue samples. We designed a new dual-band full-range FD-OCT imaging system and developed an algorithm to compensate depth-related fall-off and light attenuation. In our imaging system, the images from two wavelength bands were intrinsically overlapped and their intensities were balanced. The processing time of dual-band OCT image reconstruction and depth-related compensations were minimized by using multiple threads that execute in parallel. Using the newly developed system, we studied tissue phantoms and human cancer xenografts and muscle tissues dissected from severely compromised immune deficient mice. Improved spectroscopic contrast and sensitivity were achieved, benefiting from the depth-related compensations.

© 2013 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: October 31, 2013
Revised Manuscript: December 5, 2013
Manuscript Accepted: December 6, 2013
Published: December 10, 2013

Citation
Miao Zhang, Lixin Ma, and Ping Yu, "Dual-band Fourier domain optical coherence tomography with depth-related compensations," Biomed. Opt. Express 5, 167-182 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-1-167


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