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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 1 — Jan. 1, 2014
  • pp: 223–232

High frame-rate intravascular optical frequency-domain imaging in vivo

Han Saem Cho, Sun-Joo Jang, Kyunghun Kim, Alexey V. Dan-Chin-Yu, Milen Shishkov, Brett E. Bouma, and Wang-Yuhl Oh  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 1, pp. 223-232 (2014)
http://dx.doi.org/10.1364/BOE.5.000223


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Abstract

Intravascular optical frequency-domain imaging (OFDI), a second-generation optical coherence tomography (OCT) technology, enables imaging of the three-dimensional (3D) microstructure of the vessel wall following a short and nonocclusive clear liquid flush. Although 3D vascular visualization provides a greater appreciation of the vessel wall and intraluminal structures, a longitudinal imaging pitch that is several times bigger than the optical imaging resolution of the system has limited true high-resolution 3D imaging, mainly due to the slow scanning speed of previous imaging catheters. Here, we demonstrate high frame-rate intravascular OFDI in vivo, acquiring images at a rate of 350 frames per second. A custom-built, high-speed, and high-precision fiber-optic rotary junction provided uniform and high-speed beam scanning through a custom-made imaging catheter with an outer diameter of 0.87 mm. A 47-mm-long rabbit aorta was imaged in 3.7 seconds after a short contrast agent flush. The longitudinal imaging pitch was 34 μm, comparable to the transverse imaging resolution of the system. Three-dimensional volume-rendering showed greatly enhanced visualization of tissue microstructure and stent struts relative to what is provided by conventional intravascular imaging speeds.

© 2013 Optical Society of America

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: September 10, 2013
Revised Manuscript: October 31, 2013
Manuscript Accepted: December 10, 2013
Published: December 16, 2013

Citation
Han Saem Cho, Sun-Joo Jang, Kyunghun Kim, Alexey V. Dan-Chin-Yu, Milen Shishkov, Brett E. Bouma, and Wang-Yuhl Oh, "High frame-rate intravascular optical frequency-domain imaging in vivo," Biomed. Opt. Express 5, 223-232 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-1-223


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