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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 1 — Jan. 1, 2014
  • pp: 259–274

Quantitative assessment of oral mucosa and labial minor salivary glands in patients with Sjögren’s syndrome using swept source OCT

Ireneusz Grulkowski, Jan K. Nowak, Karol Karnowski, Paweł Zebryk, Mariusz Puszczewicz, Jaroslaw Walkowiak, and Maciej Wojtkowski  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 1, pp. 259-274 (2014)
http://dx.doi.org/10.1364/BOE.5.000259


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Abstract

Three-dimensional imaging of the mucosa of the lower lip and labial minor salivary glands is demonstrated in vivo using swept source optical coherence tomography (OCT) system at 1310 nm with modified interface. Volumetric data sets of the inner surface of the lower lip covering ~230 mm2 field are obtained from patients with Sjögren’s syndrome and a control group. OCT enables high-resolution visualization of mucosal architecture using cross-sectional images as well as en-face projection images. Comprehensive morphometry of the labial minor salivary glands is performed, and statistical significance is assessed. Statistically significant differences in morphometric parameters are found when subgroups of patients with Sjögren’s syndrome are analyzed.

© 2013 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6930) Medical optics and biotechnology : Tissue

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: October 23, 2013
Revised Manuscript: November 26, 2013
Manuscript Accepted: November 26, 2013
Published: December 16, 2013

Citation
Ireneusz Grulkowski, Jan K. Nowak, Karol Karnowski, Paweł Zebryk, Mariusz Puszczewicz, Jaroslaw Walkowiak, and Maciej Wojtkowski, "Quantitative assessment of oral mucosa and labial minor salivary glands in patients with Sjögren’s syndrome using swept source OCT," Biomed. Opt. Express 5, 259-274 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-1-259


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References

  1. A. Tincani, L. Andreoli, I. Cavazzana, A. Doria, M. Favero, M.-G. Fenini, F. Franceschini, A. Lojacono, G. Nascimbeni, A. Santoro, F. Semeraro, P. Toniati, and Y. Shoenfeld, “Novel aspects of Sjögren’s syndrome in 2012,” BMC Med.11(1), 93 (2013). [CrossRef] [PubMed]
  2. C. Baldini, R. Talarico, A. G. Tzioufas, and S. Bombardieri, “Classification criteria for Sjogren’s syndrome: a critical review,” J. Autoimmun.39(1-2), 9–14 (2012). [CrossRef] [PubMed]
  3. Y. Shapira, N. Agmon-Levin, and Y. Shoenfeld, “Geoepidemiology of autoimmune rheumatic diseases,” Nat Rev Rheumatol6(8), 468–476 (2010). [CrossRef] [PubMed]
  4. S. A. Mathews, B. T. Kurien, and R. H. Scofield, “Oral Manifestations of Sjögren’s Syndrome,” J. Dent. Res.87(4), 308–318 (2008). [CrossRef] [PubMed]
  5. M. Bell, A. Askari, A. Bookman, S. Frydrych, J. Lamont, J. McComb, C. Muscoplat, and A. Slomovic, “Sjögren’s syndrome: A critical review of clinical management,” J. Rheumatol.26(9), 2051–2061 (1999). [PubMed]
  6. M. Lee, J. A. Rutka, A. R. Slomovic, J. McComb, D. J. Bailey, and A. A. M. Bookman, “Establishing guidelines for the role of minor salivary gland biopsy in clinical practice for Sjögren’s syndrome,” J. Rheumatol.25(2), 247–253 (1998). [PubMed]
  7. D. Guellec, D. Cornec, S. Jousse-Joulin, T. Marhadour, P. Marcorelles, J.-O. Pers, A. Saraux, and V. Devauchelle-Pensec, “Diagnostic value of labial minor salivary gland biopsy for Sjögren’s syndrome: A systematic review,” Autoimmun. Rev.12(3), 416–420 (2013). [CrossRef] [PubMed]
  8. S. Y. Lee, S. J. Han, S. M. Nam, S. C. Yoon, J. M. Ahn, T.-I. Kim, E. K. Kim, and K. Y. Seo, “Analysis of tear cytokines and clinical correlations in Sjögren cyndrome dry eye patients and non-Sjögren syndrome dry eye patients,” Am. J. Ophthalmol.156(2), 247–253 (2013).
  9. S. C. Shiboski, C. H. Shiboski, L. A. Criswell, A. N. Baer, S. Challacombe, H. Lanfranchi, M. Schiødt, H. Umehara, F. Vivino, Y. Zhao, Y. Dong, D. Greenspan, A. M. Heidenreich, P. Helin, B. Kirkham, K. Kitagawa, G. Larkin, M. Li, T. Lietman, J. Lindegaard, N. McNamara, K. Sack, P. Shirlaw, S. Sugai, C. Vollenweider, J. Whitcher, A. Wu, S. Zhang, W. Zhang, J. S. Greenspan, and T. E. Daniels, “American College of Rheumatology classification criteria for Sjögren’s syndrome: A data-driven, expert consensus approach in the Sjögren’s International Collaborative Clinical Alliance Cohort,” Arth. Care Res.64(4), 475–487 (2012). [CrossRef]
  10. C. J. Burke, R. H. Thomas, and D. Howlett, “Imaging the major salivary glands,” Br. J. Oral Maxillofac. Surg.49(4), 261–269 (2011). [CrossRef] [PubMed]
  11. W. W. I. Kalk, A. Vissink, F. K. L. Spijkervet, H. Bootsma, C. G. M. Kallenberg, and J. L. N. Roodenburg, “Parotid sialography for diagnosing Sjögren syndrome,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.94(1), 131–137 (2002). [CrossRef] [PubMed]
  12. L. S. de Clerck, R. Corthouts, L. Francx, C. Brussaard, A. de Schepper, H. A. Vercruysse, and W. J. Stevens, “Ultrasonography and computer tomography of the salivary glands in the evaluation of Sjögren’s syndrome. comparison with parotid sialography,” J. Rheumatol.15(12), 1777–1781 (1988). [PubMed]
  13. I. Umehara, I. Yamada, Y. Murata, Y. Takahashi, N. Okada, and H. Shibuya, “Quantitative evaluation of salivary gland scintigraphy in Sjörgen’s syndrome,” J. Nucl. Med.40(1), 64–69 (1999). [PubMed]
  14. H. Tonami, K. Higashi, M. Matoba, H. Yokota, I. Yamamoto, and S. Sugai, “A comparative study between MR sialography and salivary gland scintigraphy in the diagnosis of Sjögren syndrome,” J. Comput. Assist. Tomogr.25(2), 262–268 (2001). [CrossRef] [PubMed]
  15. P. Zengel, F. Schrötzlmair, C. Reichel, P. Paprottka, and D. A. Clevert, “Sonography: The Leading Diagnostic Tool for Diseases of the Salivary Glands,” Semin. Ultrasound CT MR34(3), 196–203 (2013). [CrossRef] [PubMed]
  16. M. Sumi, T. Yamada, Y. Takagi, and T. Nakamura, “MR imaging of labial glands,” AJNR Am. J. Neuroradiol.28(8), 1552–1556 (2007). [CrossRef] [PubMed]
  17. A. Uchugonova and K. König, “Two-photon autofluorescence and second-harmonic imaging of adult stem cells,” J. Biomed. Opt.13(5), 054068 (2008). [CrossRef] [PubMed]
  18. D. Beroukas, J. Hiscock, R. Jonsson, S. A. Waterman, and T. P. Gordon, “Subcellular distribution of aquaporin 5 in salivary glands in primary Sjögren’s syndrome,” Lancet358(9296), 1875–1876 (2001). [CrossRef] [PubMed]
  19. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical coherence tomography,” Science254(5035), 1178–1181 (1991). [CrossRef] [PubMed]
  20. T. H. Ko, D. C. Adler, J. G. Fujimoto, D. Mamedov, V. Prokhorov, V. Shidlovski, and S. Yakubovich, “Ultrahigh resolution optical coherence tomography imaging with a broadband superluminescent diode light source,” Opt. Express12(10), 2112–2119 (2004). [CrossRef] [PubMed]
  21. R. A. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, and A. F. Fercher, “Ultrahigh resolution Fourier domain optical coherence tomography,” Opt. Express12(10), 2156–2165 (2004). [CrossRef] [PubMed]
  22. W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-Megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express18(14), 14685–14704 (2010). [CrossRef] [PubMed]
  23. M. Wojtkowski, “High-speed optical coherence tomography: basics and applications,” Appl. Opt.49(16), D30–D61 (2010). [CrossRef] [PubMed]
  24. M. A. Choma, M. V. Sarunic, C. H. Yang, and J. A. Izatt, “Sensitivity advantage of swept source and Fourier domain optical coherence tomography,” Opt. Express11(18), 2183–2189 (2003). [CrossRef] [PubMed]
  25. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, “Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography,” Opt. Lett.28(21), 2067–2069 (2003). [CrossRef] [PubMed]
  26. R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, “Performance of fourier domain vs. time domain optical coherence tomography,” Opt. Express11(8), 889–894 (2003). [CrossRef] [PubMed]
  27. S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, “Optical coherence tomography using a frequency-tunable optical source,” Opt. Lett.22(5), 340–342 (1997). [CrossRef] [PubMed]
  28. R. Huber, M. Wojtkowski, and J. G. Fujimoto, “Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography,” Opt. Express14(8), 3225–3237 (2006). [CrossRef] [PubMed]
  29. G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science276(5321), 2037–2039 (1997). [CrossRef] [PubMed]
  30. S. A. Boppart, B. E. Bouma, C. Pitris, G. J. Tearney, J. G. Fujimoto, and M. E. Brezinski, “Forward-imaging instruments for optical coherence tomography,” Opt. Lett.22(21), 1618–1620 (1997). [CrossRef] [PubMed]
  31. F. Feldchtein, G. Gelikonov, V. Gelikonov, R. Kuranov, A. Sergeev, N. Gladkova, A. Shakhov, N. Shakhova, L. Snopova, A. Terent’eva, E. Zagainova, Y. Chumakov, and I. Kuznetzova, “Endoscopic applications of optical coherence tomography,” Opt. Express3(6), 257–270 (1998). [CrossRef] [PubMed]
  32. A. Sergeev, V. Gelikonov, G. Gelikonov, F. Feldchtein, R. Kuranov, N. Gladkova, N. Shakhova, L. Snopova, A. Shakhov, I. Kuznetzova, A. Denisenko, V. Pochinko, Y. Chumakov, and O. Streltzova, “In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa,” Opt. Express1(13), 432–440 (1997). [CrossRef] [PubMed]
  33. S. A. Boppart, A. Goodman, J. Libus, C. Pitris, C. A. Jesser, M. E. Brezinski, and J. G. Fujimoto, “High resolution imaging of endometriosis and ovarian carcinoma with optical coherence tomography: feasibility for laparoscopic-based imaging,” Br. J. Obstet. Gynaecol.106(10), 1071–1077 (1999). [CrossRef] [PubMed]
  34. N. Hanna, D. Saltzman, D. Mukai, Z. Chen, S. Sasse, J. Milliken, S. Guo, W. Jung, H. Colt, and M. Brenner, “Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura,” J. Thorac. Cardiovasc. Surg.129(3), 615–622 (2005). [CrossRef] [PubMed]
  35. D. C. Adler, C. Zhou, T.-H. Tsai, J. Schmitt, Q. Huang, H. Mashimo, and J. G. Fujimoto, “Three-dimensional endomicroscopy of the human colon using optical coherence tomography,” Opt. Express17(2), 784–796 (2009). [CrossRef] [PubMed]
  36. E. Sattler, R. Kästle, and J. Welzel, “Optical coherence tomography in dermatology,” J. Biomed. Opt.18(6), 061224 (2013). [CrossRef] [PubMed]
  37. F. I. Feldchtein, V. Gelikonov, R. Iksanov, G. Gelikonov, R. V. Kuranov, A. M. Sergeev, N. D. Gladkova, M. N. Ourutina, D. Reitze, and J. Warren, “In vivo OCT imaging of hard and soft tissue of the oral cavity,” Opt. Express3(6), 239–250 (1998). [CrossRef] [PubMed]
  38. J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. F. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg.132(10), 1074–1081 (2006). [CrossRef] [PubMed]
  39. M. T. Tsai, H. C. Lee, C. K. Lee, C. H. Yu, H. M. Chen, C. P. Chiang, C. C. Chang, Y. M. Wang, and C. C. Yang, “Effective indicators for diagnosis of oral cancer using optical coherence tomography,” Opt. Express16(20), 15847–15862 (2008). [CrossRef] [PubMed]
  40. C.-K. Lee, M.-T. Tsai, H.-C. Lee, H.-M. Chen, C.-P. Chiang, Y.-M. Wang, and C. C. Yang, “Diagnosis of oral submucous fibrosis with optical coherence tomography,” J. Biomed. Opt.14(5), 054008 (2009). [CrossRef] [PubMed]
  41. N. Ozawa, Y. Sumi, K. Shimozato, C. Chong, and T. Kurabayashi, “In vivo imaging of human labial glands using advanced optical coherence tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.108(3), 425–429 (2009). [CrossRef] [PubMed]
  42. L. L. Otis, D. Q. Piao, C. W. Gibson, and Q. Zhu, “Quantifying labial blood flow using optical Doppler tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.98(2), 189–194 (2004). [CrossRef] [PubMed]
  43. C. Vitali, S. Bombardieri, R. Jonsson, H. M. Moutsopoulos, E. L. Alexander, S. E. Carsons, T. E. Daniels, P. C. Fox, R. I. Fox, S. S. Kassan, S. R. Pillemer, N. Talal, M. H. Weisman, and European Study Group on Classification Criteria for Sjögren’s Syndrome, “Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group,” Ann. Rheum. Dis.61(6), 554–558 (2002). [CrossRef] [PubMed]
  44. A. M. Lindvall and R. Jonsson, “The salivary gland component of Sjögren’s syndrome: An evaluation of diagnostic methods,” Oral Surg. Oral Med. Oral Pathol.62(1), 32–42 (1986). [CrossRef] [PubMed]
  45. C. Baeteman, L. Guyot, J. Bouvenot, C. Chossegros, F. Cheynet, C. Loudot, J. Serratrice, and S. Attarian, “Should minor salivary gland biopsy still be performed?” Rev. Stomatol. Chir. Maxillofac.109(3), 143–147 (2008). [CrossRef] [PubMed]
  46. M. Lida Santiago, M. R. Seisdedos, R. N. García Salinas, A. Secco, L. Marino Claverie, L. Techera, L. Takashima, P. Aicardi, M. A. Sandi Rosales, E. Knobel, S. J. Magri, and A. C. Catalán Pellet, “Frequency of Complications and Usefulness of the Minor Salivary Gland Biopsy,” Reumatol. Clín.8, 255–258 (2012).
  47. ANSI, American National Standard for Safe Use of Lasers ANSI Z136.1–2007 (Laser Institute of America, Orlando, 2007), pp. 1–249.
  48. J. Schindelin, I. Arganda-Carreras, E. Frise, V. Kaynig, M. Longair, T. Pietzsch, S. Preibisch, C. Rueden, S. Saalfeld, B. Schmid, J.-Y. Tinevez, D. J. White, V. Hartenstein, K. Eliceiri, P. Tomancak, and A. Cardona, “Fiji: an open-source platform for biological-image analysis,” Nat. Methods9(7), 676–682 (2012). [CrossRef] [PubMed]
  49. T. Inamura, C. Ino, M. Katoh, A. Kishimoto, H. Kumazawa, A. Matsumoto, and T. Yamashita, “A Simple Method to Estimate the Secretion of Saliva From Minor Salivary Glands Using Iodine-Starch Reaction,” Laryngoscope111(2), 272–277 (2001). [CrossRef] [PubMed]
  50. J. Pijpe, J. M. Meijer, H. Bootsma, J. E. van der Wal, F. K. L. Spijkervet, C. G. M. Kallenberg, A. Vissink, and S. Ihrler, “Clinical and histologic evidence of salivary gland restoration supports the efficacy of rituximab treatment in Sjögren’s syndrome,” Arthritis Rheum.60(11), 3251–3256 (2009). [CrossRef] [PubMed]
  51. R. Bamba, N. J. Sweiss, A. J. Langerman, J. B. Taxy, and E. A. Blair, “The minor salivary gland biopsy as a diagnostic tool for Sjogren syndrome,” Laryngoscope119(10), 1922–1926 (2009). [CrossRef] [PubMed]
  52. N. Iwata, T. Miyamae, M. Kikuchi, T. Kishi, R. Hara, U. Kaneko, T. Shinoki, T. Imagawa, Y. Inayama, and S. Yokota, “Clinical and histological experience of labial lip biopsy in juvenile Sjögren syndrome [in Japanese],” Nihon Rinsho Meneki Gakkai Kaishi32(3), 195–200 (2009). [CrossRef] [PubMed]
  53. P. Z. Wang, Q. Lu, S. L. Chen, and Y. H. Jiang, “[The pathological changes of lip biopsies and dental caries on Sjogren’s syndrome],” Shanghai Kou Qiang Yi Xue2(2), 77–79 (1993). [PubMed]
  54. A. M. Pedersen, A. Bardow, and B. Nauntofte, “Salivary changes and dental caries as potential oral markers of autoimmune salivary gland dysfunction in primary Sjogren’s syndrome,” BMC Clin. Pathol.5(1), 4 (2005). [CrossRef] [PubMed]
  55. A. Tandon, N. N. Singh, and G. Sreedhar, “Minor salivary glands and dental caries: Approach towards a new horizon,” J. Nat. Sci. Biol. Med.4(2), 364–368 (2013). [CrossRef] [PubMed]
  56. M. García-Carrasco, A. Sisó, M. Ramos-Casals, J. Rosas, G. de la Red, V. Gil, S. Lasterra, R. Cervera, J. Font, and M. Ingelmo, “Raynaud’s phenomenon in primary Sjögren’s syndrome. Prevalence and clinical characteristics in a series of 320 patients,” J. Rheumatol.29(4), 726–730 (2002). [PubMed]
  57. Cda. M. Brasil, C. M. Ribeiro, D. D. Fonseca, L. A. Gueiros, and J. C. Leao, “Chloroquine-induced hyperpigmentation of the hard palate,” Gen. Dent.60(2), e74–e78 (2012). [PubMed]
  58. L. J. Dawson, V. L. Caulfield, J. B. Stanbury, A. E. Field, S. E. Christmas, and P. M. Smith, “Hydroxychloroquine therapy in patients with primary Sjögren’s syndrome may improve salivary gland hypofunction by inhibition of glandular cholinesterase,” Rheumatology (Oxford)44(4), 449–455 (2005). [CrossRef] [PubMed]

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