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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 1 — Jan. 1, 2014
  • pp: 259–274

Quantitative assessment of oral mucosa and labial minor salivary glands in patients with Sjögren’s syndrome using swept source OCT

Ireneusz Grulkowski, Jan K. Nowak, Karol Karnowski, Paweł Zebryk, Mariusz Puszczewicz, Jaroslaw Walkowiak, and Maciej Wojtkowski  »View Author Affiliations

Biomedical Optics Express, Vol. 5, Issue 1, pp. 259-274 (2014)

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Three-dimensional imaging of the mucosa of the lower lip and labial minor salivary glands is demonstrated in vivo using swept source optical coherence tomography (OCT) system at 1310 nm with modified interface. Volumetric data sets of the inner surface of the lower lip covering ~230 mm2 field are obtained from patients with Sjögren’s syndrome and a control group. OCT enables high-resolution visualization of mucosal architecture using cross-sectional images as well as en-face projection images. Comprehensive morphometry of the labial minor salivary glands is performed, and statistical significance is assessed. Statistically significant differences in morphometric parameters are found when subgroups of patients with Sjögren’s syndrome are analyzed.

© 2013 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6930) Medical optics and biotechnology : Tissue

ToC Category:
Optical Coherence Tomography

Original Manuscript: October 23, 2013
Revised Manuscript: November 26, 2013
Manuscript Accepted: November 26, 2013
Published: December 16, 2013

Ireneusz Grulkowski, Jan K. Nowak, Karol Karnowski, Paweł Zebryk, Mariusz Puszczewicz, Jaroslaw Walkowiak, and Maciej Wojtkowski, "Quantitative assessment of oral mucosa and labial minor salivary glands in patients with Sjögren’s syndrome using swept source OCT," Biomed. Opt. Express 5, 259-274 (2014)

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