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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 1 — Jan. 1, 2014
  • pp: 275–286

In vitro glucose measurement using tunable mid-infrared laser spectroscopy combined with fiber-optic sensor

Songlin Yu, Dachao Li, Hao Chong, Changyue Sun, Haixia Yu, and Kexin Xu  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 1, pp. 275-286 (2014)
http://dx.doi.org/10.1364/BOE.5.000275


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Abstract

Because mid-infrared (mid-IR) spectroscopy is not a promising method to noninvasively measure glucose in vivo, a method for minimally invasive high-precision glucose determination in vivo by mid-IR laser spectroscopy combined with a tunable laser source and small fiber-optic attenuated total reflection (ATR) sensor is introduced. The potential of this method was evaluated in vitro. This research presents a mid-infrared tunable laser with a broad emission spectrum band of 9.19 to 9.77 μm (1024~1088 cm−1) and proposes a method to control and stabilize the laser emission wavelength and power. Moreover, several fiber-optic ATR sensors were fabricated and investigated to determine glucose in combination with the tunable laser source, and the effective sensing optical length of these sensors was determined for the first time. In addition, the sensitivity of this system was four times that of a Fourier transform infrared (FT-IR) spectrometer. The noise-equivalent concentration (NEC) of this laser measurement system was as low as 3.8 mg/dL, which is among the most precise glucose measurements using mid-infrared spectroscopy. Furthermore, a partial least-squares regression and Clarke error grid were used to quantify the predictability and evaluate the prediction accuracy of glucose concentration in the range of 5 to 500 mg/dL (physiologically relevant range: 30~400 mg/dL). The experimental results were clinically acceptable. The high sensitivity, tunable laser source, low NEC and small fiber-optic ATR sensor demonstrate an encouraging step in the work towards precisely monitoring glucose levels in vivo.

© 2013 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(300.1030) Spectroscopy : Absorption
(300.6340) Spectroscopy : Spectroscopy, infrared

ToC Category:
Noninvasive Optical Diagnostics

History
Original Manuscript: October 21, 2013
Revised Manuscript: December 6, 2013
Manuscript Accepted: December 7, 2013
Published: December 17, 2013

Citation
Songlin Yu, Dachao Li, Hao Chong, Changyue Sun, Haixia Yu, and Kexin Xu, "In vitro glucose measurement using tunable mid-infrared laser spectroscopy combined with fiber-optic sensor," Biomed. Opt. Express 5, 275-286 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-1-275


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