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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 1 — Jan. 1, 2014
  • pp: 9–15

In vivo optical spectroscopy for improved detection of pancreatic adenocarcinoma: a feasibility study

William R. Lloyd, Robert H. Wilson, Seung Yup Lee, Malavika Chandra, Barbara McKenna, Diane Simeone, James Scheiman, and Mary-Ann Mycek  »View Author Affiliations

Biomedical Optics Express, Vol. 5, Issue 1, pp. 9-15 (2014)

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Pancreatic adenocarcinoma has a five-year survival rate of less than 6%. This low survival rate is attributed to the lack of accurate detection methods, which limits diagnosis to late-stage disease. Here, an in vivo pilot study assesses the feasibility of optical spectroscopy to improve clinical detection of pancreatic adenocarcinoma. During surgery on 6 patients, we collected spectrally-resolved reflectance and fluorescence in vivo. Site-matched in vivo and ex vivo data agreed qualitatively and quantitatively. Quantified differences between adenocarcinoma and normal tissues in vivo were consistent with previous results from a large ex vivo data set. Thus, optical spectroscopy is a promising method for the improved diagnosis of pancreatic cancer in vivo.

© 2013 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Optics in Cancer Research

Original Manuscript: July 23, 2013
Revised Manuscript: October 24, 2013
Manuscript Accepted: November 19, 2013
Published: December 2, 2013

Virtual Issues
Advances in Optics for Biotechnology, Medicine and Surgery (2013) Biomedical Optics Express

William R. Lloyd, Robert H. Wilson, Seung Yup Lee, Malavika Chandra, Barbara McKenna, Diane Simeone, James Scheiman, and Mary-Ann Mycek, "In vivo optical spectroscopy for improved detection of pancreatic adenocarcinoma: a feasibility study," Biomed. Opt. Express 5, 9-15 (2014)

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