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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 2 — Feb. 1, 2014
  • pp: 596–608

Synthesis and characterization of biocompatible nanodiamond-silk hybrid material

Asma Khalid, Rebecca Lodin, Peter Domachuk, Hu Tao, Jodie E. Moreau, David L. Kaplan, Fiorenzo G. Omenetto, Brant C. Gibson, and Snjezana Tomljenovic-Hanic  »View Author Affiliations

Biomedical Optics Express, Vol. 5, Issue 2, pp. 596-608 (2014)

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A new hybrid material consisting of nanodiamonds (NDs) and silk has been synthesized and investigated. NDs can contain bright fluorescence centers, important for bioprobes to image biological structures at the nanoscale and silk provides a transparent, robust matrix for these nanoparticles in-vivo or in-vitro. The ND-silk hybrid films were determined to be highly transparent in the visible to near infrared wavelength range. The NDs embedded in silk exhibited significant enhancement of emission relative to air, correlating with theoretical predictions. Furthermore, animal toxicity tests confirmed ND-silk films to be non-toxic in an in-vivo mice model.

© 2014 Optical Society of America

OCIS Codes
(180.1790) Microscopy : Confocal microscopy
(300.2530) Spectroscopy : Fluorescence, laser-induced
(160.4236) Materials : Nanomaterials

ToC Category:
Nanotechnology and Plasmonics

Original Manuscript: September 17, 2013
Revised Manuscript: November 27, 2013
Manuscript Accepted: December 12, 2013
Published: January 27, 2014

Asma Khalid, Rebecca Lodin, Peter Domachuk, Hu Tao, Jodie E. Moreau, David L. Kaplan, Fiorenzo G. Omenetto, Brant C. Gibson, and Snjezana Tomljenovic-Hanic, "Synthesis and characterization of biocompatible nanodiamond-silk hybrid material," Biomed. Opt. Express 5, 596-608 (2014)

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