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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 2 — Feb. 1, 2014
  • pp: 609–620

Characterization of eosinophilic esophagitis murine models using optical coherence tomography

Aneesh Alex, Mario Noti, Elia D. Tait Wojno, David Artis, and Chao Zhou  »View Author Affiliations

Biomedical Optics Express, Vol. 5, Issue 2, pp. 609-620 (2014)

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Pre-clinical studies using murine models are critical for understanding the pathophysiological mechanisms underlying immune-mediated disorders such as Eosinophilic esophagitis (EoE). In this study, an optical coherence tomography (OCT) system capable of providing three-dimensional images with axial and transverse resolutions of 5 µm and 10 µm, respectively, was utilized to obtain esophageal images from a murine model of EoE-like disease ex vivo. Structural changes in the esophagus of wild-type (Tslpr+/+) and mutant (Tslpr−/−) mice with EoE-like disease were quantitatively evaluated and food impaction sites in the esophagus of diseased mice were monitored using OCT. Here, the capability of OCT as a label-free imaging tool devoid of tissue-processing artifacts to effectively characterize murine EoE-like disease models has been demonstrated.

© 2014 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(110.6880) Imaging systems : Three-dimensional image acquisition
(170.0110) Medical optics and biotechnology : Imaging systems
(170.2680) Medical optics and biotechnology : Gastrointestinal
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Gastroenterology Applications

Original Manuscript: November 14, 2013
Revised Manuscript: January 17, 2014
Manuscript Accepted: January 18, 2014
Published: January 27, 2014

Aneesh Alex, Mario Noti, Elia D. Tait Wojno, David Artis, and Chao Zhou, "Characterization of eosinophilic esophagitis murine models using optical coherence tomography," Biomed. Opt. Express 5, 609-620 (2014)

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