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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 2 — Feb. 1, 2014
  • pp: 621–629

Assessment of local structural disorders of the bladder wall in partial bladder outlet obstruction using polarized light imaging

Sanaz Alali, Karen J. Aitken, Annette Schröder, Adam Gribble, Darius J. Bagli, and I. Alex Vitkin  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 2, pp. 621-629 (2014)
http://dx.doi.org/10.1364/BOE.5.000621


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Abstract

Partial bladder outlet obstruction causes prominent morphological changes in the bladder wall, which leads to bladder dysfunction. In this paper, we demonstrate that polarized light imaging can be used to identify the location of obstruction induced structural changes that other imaging modalities fail to detect. We induced 2-week and 6-week partial outlet obstruction in rats, harvested obstructed bladders, then measured their retardances while distended to high pressures and compared them to controls. Our results show that the retardance of the central part of the ventral side (above the ureters) closer to the urethra can be used as a potential metric of the distending bladder obstruction.

© 2014 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.7230) Medical optics and biotechnology : Urology

ToC Category:
Urology Applications

History
Original Manuscript: November 6, 2013
Revised Manuscript: January 9, 2014
Manuscript Accepted: January 13, 2014
Published: January 27, 2014

Citation
Sanaz Alali, Karen J. Aitken, Annette Schröder, Adam Gribble, Darius J. Bagli, and I. Alex Vitkin, "Assessment of local structural disorders of the bladder wall in partial bladder outlet obstruction using polarized light imaging," Biomed. Opt. Express 5, 621-629 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-2-621


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