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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 3 — Mar. 1, 2014
  • pp: 713–727

Microstructure of subretinal drusenoid deposits revealed by adaptive optics imaging

Alexander Meadway, Xiaolin Wang, Christine A. Curcio, and Yuhua Zhang  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 3, pp. 713-727 (2014)
http://dx.doi.org/10.1364/BOE.5.000713


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Abstract

Subretinal drusenoid deposits (SDD), a recently recognized lesion associated with progression of age-related macular degeneration, were imaged with adaptive optics scanning laser ophthalmoscopy (AO-SLO) and optical coherence tomography (AO-OCT). AO-SLO revealed a distinct en face structure of stage 3 SDD, showing a hyporeflective annulus surrounded reflective core packed with hyperreflective dots bearing a superficial similarity to the photoreceptors in the unaffected retina. However, AO-OCT suggested that the speckled appearance over the SDD rendered by AO-SLO was the lesion material itself, rather than photoreceptors. AO-OCT assists proper interpretation and understanding of the SDD structure and the lesions’ impact on surrounding photoreceptors produced by AO-SLO and vice versa.

© 2014 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(330.5310) Vision, color, and visual optics : Vision - photoreceptors
(330.7329) Vision, color, and visual optics : Visual optics, pathology
(110.1080) Imaging systems : Active or adaptive optics

ToC Category:
Ophthalmology Applications

History
Original Manuscript: November 14, 2013
Revised Manuscript: January 18, 2014
Manuscript Accepted: February 5, 2014
Published: February 12, 2014

Citation
Alexander Meadway, Xiaolin Wang, Christine A. Curcio, and Yuhua Zhang, "Microstructure of subretinal drusenoid deposits revealed by adaptive optics imaging," Biomed. Opt. Express 5, 713-727 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-3-713


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