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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 3 — Mar. 1, 2014
  • pp: 800–816

Neurotoxic effects of indocyanine green -cerebellar granule cell culture viability study

Beata Toczylowska, Elzbieta Zieminska, Grazyna Goch, Daniel Milej, Anna Gerega, and Adam Liebert  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 3, pp. 800-816 (2014)
http://dx.doi.org/10.1364/BOE.5.000800


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Abstract

The aim of this study was to examine neurotoxicity indocyanine green (ICG). We assessed viability of primary cerebellar granule cell culture (CGC) exposed to ICG to test two mechanisms that could be the first triggers causing neuronal toxicity: imbalance in calcium homeostasis and the degree of oligomerization of ICG molecules. We have observed this imbalance in CGC after exposure to 75-125μΜ ICG and dose and application sequence dependent protective effect of Gadovist on surviving neurons in vitro when used with ICG. Spectroscopic studies suggest the major cause of toxicity of the ICG is connected with oligomers formation. ICG at concentration of 25 μM (which is about 4 times higher than the highest concentration of ICG in the brain applied in in-vivo human studies) is not neurotoxic in the cell culture.

© 2014 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1530) Medical optics and biotechnology : Cell analysis
(170.1610) Medical optics and biotechnology : Clinical applications
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

ToC Category:
Molecular Imaging and Probe Development

History
Original Manuscript: December 17, 2013
Revised Manuscript: February 8, 2014
Manuscript Accepted: February 10, 2014
Published: February 19, 2014

Citation
Beata Toczylowska, Elzbieta Zieminska, Grazyna Goch, Daniel Milej, Anna Gerega, and Adam Liebert, "Neurotoxic effects of indocyanine green -cerebellar granule cell culture viability study," Biomed. Opt. Express 5, 800-816 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-3-800


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