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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 3 — Mar. 1, 2014
  • pp: 895–906

Optical coherence tomography detection of shear wave propagation in inhomogeneous tissue equivalent phantoms and ex-vivo carotid artery samples

Marjan Razani, Timothy W.H. Luk, Adrian Mariampillai, Peter Siegler, Tim-Rasmus Kiehl, Michael C. Kolios, and Victor X.D. Yang  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 3, pp. 895-906 (2014)
http://dx.doi.org/10.1364/BOE.5.000895


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Abstract

In this work, we explored the potential of measuring shear wave propagation using optical coherence elastography (OCE) in an inhomogeneous phantom and carotid artery samples based on a swept-source optical coherence tomography (OCT) system. Shear waves were generated using a piezoelectric transducer transmitting sine-wave bursts of 400 μs duration, applying acoustic radiation force (ARF) to inhomogeneous phantoms and carotid artery samples, synchronized with a swept-source OCT (SS-OCT) imaging system. The phantoms were composed of gelatin and titanium dioxide whereas the carotid artery samples were embedded in gel. Differential OCT phase maps, measured with and without the ARF, detected the microscopic displacement generated by shear wave propagation in these phantoms and samples of different stiffness. We present the technique for calculating tissue mechanical properties by propagating shear waves in inhomogeneous tissue equivalent phantoms and carotid artery samples using the ARF of an ultrasound transducer, and measuring the shear wave speed and its associated properties in the different layers with OCT phase maps. This method lays the foundation for future in-vitro and in-vivo studies of mechanical property measurements of biological tissues such as vascular tissues, where normal and pathological structures may exhibit significant contrast in the shear modulus.

© 2014 Optical Society of America

OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: November 4, 2013
Revised Manuscript: January 16, 2014
Manuscript Accepted: February 19, 2014
Published: February 26, 2014

Citation
Marjan Razani, Timothy W.H. Luk, Adrian Mariampillai, Peter Siegler, Tim-Rasmus Kiehl, Michael C. Kolios, and Victor X.D. Yang, "Optical coherence tomography detection of shear wave propagation in inhomogeneous tissue equivalent phantoms and ex-vivo carotid artery samples," Biomed. Opt. Express 5, 895-906 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-3-895


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