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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 4 — Apr. 1, 2014
  • pp: 990–999

Continuous noninvasive monitoring of changes in human skin optical properties during oral intake of different sugars with optical coherence tomography

Yuqing Zhang, Guoyong Wu, Huajiang Wei, Zhouyi Guo, Hongqin Yang, Yonghong He, Shusen Xie, and Ying Liu  »View Author Affiliations

Biomedical Optics Express, Vol. 5, Issue 4, pp. 990-999 (2014)

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The objective of this study was to evaluate the effects of blood glucose concentration (BGC) on in vivo human skin optical properties after oral intake of different sugars. In vivo optical properties of human skin were measured with a spectral domain optical coherence tomography (SD-OCT). Experimental results show that increase of BGC causes a decrease in the skin attenuation coefficient. And the maximum decrements in mean attenuation coefficient of skin tissue after drinking glucose, sucrose and fructose solution are 47.0%, 36.4% and 16.5% compared with that after drinking water, respectively (p < 0.05). The results also show that blood glucose levels of the forearm skin tissue are delayed compared with finger-stick blood glucose, and there are significant differences in the time delays after oral intake of different sugars. The time delay between mean attenuation coefficient and BGC after drinking glucose solution is evidently larger than that after drinking sucrose solution, and that after drinking sucrose solution is larger than that after drinking fructose solution. Our pilot studies indicate that OCT technique is capable of non-invasive, real-time, and sensitive monitoring of skin optical properties in human subjects during oral intake of different sugars.

© 2014 Optical Society of America

OCIS Codes
(100.2960) Image processing : Image analysis
(110.4500) Imaging systems : Optical coherence tomography
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Noninvasive Optical Diagnostics

Original Manuscript: December 3, 2013
Revised Manuscript: January 14, 2014
Manuscript Accepted: February 12, 2014
Published: February 28, 2014

Yuqing Zhang, Guoyong Wu, Huajiang Wei, Zhouyi Guo, Hongqin Yang, Yonghong He, Shusen Xie, and Ying Liu, "Continuous noninvasive monitoring of changes in human skin optical properties during oral intake of different sugars with optical coherence tomography," Biomed. Opt. Express 5, 990-999 (2014)

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