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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 5 — May. 1, 2014
  • pp: 1336–1354

Diffuse reflectance optical topography: location of inclusions in 3D and detectability limits

N. A. Carbone, G. R. Baez, H. A. García, M. V. Waks Serra, H. O. Di Rocco, D. I. Iriarte, J. A. Pomarico, D. Grosenick, and R. Macdonald  »View Author Affiliations

Biomedical Optics Express, Vol. 5, Issue 5, pp. 1336-1354 (2014)

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In the present contribution we investigate the images of CW diffusely reflected light for a point-like source, registered by a CCD camera imaging a turbid medium containing an absorbing lesion. We show that detection of μa variations (absorption anomalies) is achieved if images are normalized to background intensity. A theoretical analysis based on the diffusion approximation is presented to investigate the sensitivity and the limitations of our proposal and a novel procedure to find the location of the inclusions in 3D is given and tested. An analysis of the noise and its influence on the detection capabilities of our proposal is provided. Experimental results on phantoms are also given, supporting the proposed approach.

© 2014 Optical Society of America

OCIS Codes
(110.7050) Imaging systems : Turbid media
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(110.0113) Imaging systems : Imaging through turbid media

ToC Category:
Diffuse Optical Imaging

Original Manuscript: November 25, 2013
Revised Manuscript: February 6, 2014
Manuscript Accepted: February 21, 2014
Published: April 2, 2014

N. A. Carbone, G. R. Baez, H. A. García, M. V. Waks Serra, H. O. Di Rocco, D. I. Iriarte, J. A. Pomarico, D. Grosenick, and R. Macdonald, "Diffuse reflectance optical topography: location of inclusions in 3D and detectability limits," Biomed. Opt. Express 5, 1336-1354 (2014)

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