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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 5 — May. 1, 2014
  • pp: 1465–1482

Separation of superficial and cerebral hemodynamics using a single distance time-domain NIRS measurement

Alexander Jelzow, Heidrun Wabnitz, Ilias Tachtsidis, Evgeniya Kirilina, Rüdiger Brühl, and Rainer Macdonald  »View Author Affiliations

Biomedical Optics Express, Vol. 5, Issue 5, pp. 1465-1482 (2014)

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In functional near-infrared spectroscopy (fNIRS) superficial hemodynamics can mask optical signals related to brain activity. We present a method to separate superficial and cerebral absorption changes based on the analysis of changes in moments of time-of-flight distributions and a two-layered model. The related sensitivity factors were calculated from individual optical properties. The method was validated on a two-layer liquid phantom. Absorption changes in the lower layer were retrieved with an accuracy better than 20%. The method was successfully applied to in vivo data and compared to the reconstruction of homogeneous absorption changes.

© 2014 Optical Society of America

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.6920) Medical optics and biotechnology : Time-resolved imaging

ToC Category:
Optics of Tissue and Turbid Media

Original Manuscript: January 23, 2014
Revised Manuscript: March 13, 2014
Manuscript Accepted: March 24, 2014
Published: April 10, 2014

Alexander Jelzow, Heidrun Wabnitz, Ilias Tachtsidis, Evgeniya Kirilina, Rüdiger Brühl, and Rainer Macdonald, "Separation of superficial and cerebral hemodynamics using a single distance time-domain NIRS measurement," Biomed. Opt. Express 5, 1465-1482 (2014)

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