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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 6 — Jun. 1, 2014
  • pp: 1744–1756

Detection limits of confocal surface plasmon microscopy

Suejit Pechprasarn and Michael G. Somekh  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 6, pp. 1744-1756 (2014)
http://dx.doi.org/10.1364/BOE.5.001744


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Abstract

This paper applies rigorous diffraction theory to evaluate the minimum mass sensitivity of a confocal optical microscope designed to excite and detect surface plasmons operating on a planar metallic substrate. The diffraction model is compared with an intuitive ray picture which gives remarkably similar predictions. The combination of focusing the surface plasmons and accurate phase measurement mean that under favorable but achievable conditions detection of small numbers of molecules is possible, however, we argue that reliable detection of single molecules will benefit from the use of structured surfaces. System configurations needed to optimize performance are discussed.

© 2014 Optical Society of America

OCIS Codes
(060.4080) Fiber optics and optical communications : Modulation
(110.0110) Imaging systems : Imaging systems
(120.0120) Instrumentation, measurement, and metrology : Instrumentation, measurement, and metrology
(180.0180) Microscopy : Microscopy

ToC Category:
Microscopy

History
Original Manuscript: January 13, 2014
Revised Manuscript: March 7, 2014
Manuscript Accepted: March 19, 2014
Published: May 6, 2014

Citation
Suejit Pechprasarn and Michael G. Somekh, "Detection limits of confocal surface plasmon microscopy," Biomed. Opt. Express 5, 1744-1756 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-6-1744


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