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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 6 — Jun. 1, 2014
  • pp: 1941–1951

Registration of adaptive optics corrected retinal nerve fiber layer (RNFL) images

Gomathy Ramaswamy, Marco Lombardo, and Nicholas Devaney  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 6, pp. 1941-1951 (2014)
http://dx.doi.org/10.1364/BOE.5.001941


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Abstract

Glaucoma is the leading cause of preventable blindness in the western world. Investigation of high-resolution retinal nerve fiber layer (RNFL) images in patients may lead to new indicators of its onset. Adaptive optics (AO) can provide diffraction-limited images of the retina, providing new opportunities for earlier detection of neuroretinal pathologies. However, precise processing is required to correct for three effects in sequences of AO-assisted, flood-illumination images: uneven illumination, residual image motion and image rotation. This processing can be challenging for images of the RNFL due to their low contrast and lack of clearly noticeable features. Here we develop specific processing techniques and show that their application leads to improved image quality on the nerve fiber bundles. This in turn improves the reliability of measures of fiber texture such as the correlation of Gray-Level Co-occurrence Matrix (GLCM).

© 2014 Optical Society of America

OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(100.2960) Image processing : Image analysis
(170.4470) Medical optics and biotechnology : Ophthalmology

ToC Category:
Ophthalmology Applications

History
Original Manuscript: February 18, 2014
Revised Manuscript: March 31, 2014
Manuscript Accepted: April 18, 2014
Published: May 22, 2014

Citation
Gomathy Ramaswamy, Marco Lombardo, and Nicholas Devaney, "Registration of adaptive optics corrected retinal nerve fiber layer (RNFL) images," Biomed. Opt. Express 5, 1941-1951 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-6-1941


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