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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 7 — Jul. 1, 2014
  • pp: 1980–1992

Noncontact quantitative biomechanical characterization of cardiac muscle using shear wave imaging optical coherence tomography

Shang Wang, Andrew L. Lopez, III, Yuka Morikawa, Ge Tao, Jiasong Li, Irina V. Larina, James F. Martin, and Kirill V. Larin  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 7, pp. 1980-1992 (2014)
http://dx.doi.org/10.1364/BOE.5.001980


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Abstract

We report on a quantitative optical elastographic method based on shear wave imaging optical coherence tomography (SWI-OCT) for biomechanical characterization of cardiac muscle through noncontact elasticity measurement. The SWI-OCT system employs a focused air-puff device for localized loading of the cardiac muscle and utilizes phase-sensitive OCT to monitor the induced tissue deformation. Phase information from the optical interferometry is used to reconstruct 2-D depth-resolved shear wave propagation inside the muscle tissue. Cross-correlation of the displacement profiles at various spatial locations in the propagation direction is applied to measure the group velocity of the shear waves, based on which the Young’s modulus of tissue is quantified. The quantitative feature and measurement accuracy of this method is demonstrated from the experiments on tissue-mimicking phantoms with the verification using uniaxial compression test. The experiments are performed on ex vivo cardiac muscle tissue from mice with normal and genetically altered myocardium. Our results indicate this optical elastographic technique is useful as a noncontact tool to assist the cardiac muscle studies.

© 2014 Optical Society of America

OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: April 15, 2014
Revised Manuscript: May 21, 2014
Manuscript Accepted: May 23, 2014
Published: May 30, 2014

Citation
Shang Wang, Andrew L. Lopez, Yuka Morikawa, Ge Tao, Jiasong Li, Irina V. Larina, James F. Martin, and Kirill V. Larin, "Noncontact quantitative biomechanical characterization of cardiac muscle using shear wave imaging optical coherence tomography," Biomed. Opt. Express 5, 1980-1992 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-7-1980


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