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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 7 — Jul. 1, 2014
  • pp: 2091–2112

Probability method for Cerenkov luminescence tomography based on conformance error minimization

Xintao Ding, Kun Wang, Biao Jie, Yonglong Luo, Zhenhua Hu, and Jie Tian  »View Author Affiliations

Biomedical Optics Express, Vol. 5, Issue 7, pp. 2091-2112 (2014)

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Cerenkov luminescence tomography (CLT) was developed to reconstruct a three-dimensional (3D) distribution of radioactive probes inside a living animal. Reconstruction methods are generally performed within a unique framework by searching for the optimum solution. However, the ill-posed aspect of the inverse problem usually results in the reconstruction being non-robust. In addition, the reconstructed result may not match reality since the difference between the highest and lowest uptakes of the resulting radiotracers may be considerably large, therefore the biological significance is lost. In this paper, based on the minimization of a conformance error, a probability method is proposed that consists of qualitative and quantitative modules. The proposed method first pinpoints the organ that contains the light source. Next, we developed a 0-1 linear optimization subject to a space constraint to model the CLT inverse problem, which was transformed into a forward problem by employing a region growing method to solve the optimization. After running through all of the elements used to grow the sources, a source sequence was obtained. Finally, the probability of each discrete node being the light source inside the organ was reconstructed. One numerical study and two in vivo experiments were conducted to verify the performance of the proposed algorithm, and comparisons were carried out using the hp-finite element method (hp-FEM). The results suggested that our proposed probability method was more robust and reasonable than hp-FEM.

© 2014 Optical Society of America

OCIS Codes
(100.3190) Image processing : Inverse problems
(110.6960) Imaging systems : Tomography
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

ToC Category:
Image Reconstruction and Inverse Problems

Original Manuscript: April 9, 2014
Revised Manuscript: May 30, 2014
Manuscript Accepted: June 4, 2014
Published: June 9, 2014

Xintao Ding, Kun Wang, Biao Jie, Yonglong Luo, Zhenhua Hu, and Jie Tian, "Probability method for Cerenkov luminescence tomography based on conformance error minimization," Biomed. Opt. Express 5, 2091-2112 (2014)

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