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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 7 — Jul. 1, 2014
  • pp: 2349–2361

Magnetomotive optical coherence elastography using magnetic particles to induce mechanical waves

Adeel Ahmad, Jongsik Kim, Nahil A. Sobh, Nathan D. Shemonski, and Stephen A. Boppart  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 7, pp. 2349-2361 (2014)
http://dx.doi.org/10.1364/BOE.5.002349


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Abstract

Magnetic particles are versatile imaging agents that have found wide spread applicability in diagnostic, therapeutic, and rheology applications. In this study, we demonstrate that mechanical waves generated by a localized inclusion of magnetic nanoparticles can be used for assessment of the tissue viscoelastic properties using magnetomotive optical coherence elastography. We show these capabilities in tissue mimicking elastic and viscoelastic phantoms and in biological tissues by measuring the shear wave speed under magnetomotive excitation. Furthermore, we demonstrate the extraction of the complex shear modulus by measuring the shear wave speed at different frequencies and fitting to a Kelvin-Voigt model.

© 2014 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(260.2110) Physical optics : Electromagnetic optics
(350.0350) Other areas of optics : Other areas of optics
(350.5030) Other areas of optics : Phase
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Optical Coherence Tomography

History
Original Manuscript: May 9, 2014
Revised Manuscript: June 9, 2014
Manuscript Accepted: June 11, 2014
Published: June 18, 2014

Citation
Adeel Ahmad, Jongsik Kim, Nahil A. Sobh, Nathan D. Shemonski, and Stephen A. Boppart, "Magnetomotive optical coherence elastography using magnetic particles to induce mechanical waves," Biomed. Opt. Express 5, 2349-2361 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-7-2349


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