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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 7 — Jul. 1, 2014
  • pp: 2397–2404

Noninvasive in vivo glucose sensing on human subjects using mid-infrared light

Sabbir Liakat, Kevin A. Bors, Laura Xu, Callie M. Woods, Jessica Doyle, and Claire F. Gmachl  »View Author Affiliations

Biomedical Optics Express, Vol. 5, Issue 7, pp. 2397-2404 (2014)

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Mid-infrared quantum cascade laser spectroscopy is used to noninvasively predict blood glucose concentrations of three healthy human subjects in vivo. We utilize a hollow-core fiber based optical setup for light delivery and collection along with a broadly tunable quantum cascade laser to obtain spectra from human subjects and use standard chemo-metric techniques (namely partial least squares regression) for prediction analysis. Throughout a glucose concentration range of 80-160 mg/dL, we achieve clinically accurate predictions 84% of the time, on average. This work opens a new path to a noninvasive in vivo glucose sensor that would benefit the lives of hundreds of millions of diabetics worldwide.

© 2014 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(300.6340) Spectroscopy : Spectroscopy, infrared
(140.5965) Lasers and laser optics : Semiconductor lasers, quantum cascade

ToC Category:
Noninvasive Optical Diagnostics

Original Manuscript: April 1, 2014
Revised Manuscript: May 31, 2014
Manuscript Accepted: June 16, 2014
Published: June 23, 2014

Sabbir Liakat, Kevin A. Bors, Laura Xu, Callie M. Woods, Jessica Doyle, and Claire F. Gmachl, "Noninvasive in vivo glucose sensing on human subjects using mid-infrared light," Biomed. Opt. Express 5, 2397-2404 (2014)

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