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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 7 — Jul. 1, 2014
  • pp: 2405–2419

In-vivo imaging of psoriatic lesions with polarization multispectral dermoscopy and multiphoton microscopy

Dimitrios Kapsokalyvas, Riccardo Cicchi, Nicola Bruscino, Domenico Alfieri, Francesca Prignano, Daniela Massi, Torello Lotti, and Francesco S. Pavone  »View Author Affiliations

Biomedical Optics Express, Vol. 5, Issue 7, pp. 2405-2419 (2014)

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Psoriasis is a skin autoimmune disease characterized by hyperkeratosis, hyperproliferation of the epidermis and dilatation of dermal papillary blood vessels. Healthy skin (5 volunteers) and psoriatic lesions (3 patients) were visualized in vivo, with high contrast and resolution, with a Polarization Multispectral Dermoscope and a Multiphoton Microscope. Psoriatic features were identified and quantified. The effective diameter of the superficial blood vessels was measured at 35.2 ± 7.2 μm and the elongated dermal papillae had an effective diameter of 64.2 ± 22.6 μm. The methodologies developed could be employed for quantitative diagnostic purposes and furthermore serve as a monitoring method of the effect of personalized treatments.

© 2014 Optical Society of America

OCIS Codes
(100.2980) Image processing : Image enhancement
(170.1870) Medical optics and biotechnology : Dermatology
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.6900) Medical optics and biotechnology : Three-dimensional microscopy
(180.4315) Microscopy : Nonlinear microscopy

ToC Category:
Dermatological Applications

Original Manuscript: February 11, 2014
Revised Manuscript: April 25, 2014
Manuscript Accepted: April 28, 2014
Published: June 24, 2014

Dimitrios Kapsokalyvas, Riccardo Cicchi, Nicola Bruscino, Domenico Alfieri, Francesca Prignano, Daniela Massi, Torello Lotti, and Francesco S. Pavone, "In-vivo imaging of psoriatic lesions with polarization multispectral dermoscopy and multiphoton microscopy," Biomed. Opt. Express 5, 2405-2419 (2014)

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