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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 7 — Jul. 1, 2014
  • pp: 2446–2457

Multi-photon excited luminescence of magnetic FePt core-shell nanoparticles

K.M. Seemann and B. Kuhn  »View Author Affiliations

Biomedical Optics Express, Vol. 5, Issue 7, pp. 2446-2457 (2014)

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We present magnetic FePt nanoparticles with a hydrophilic, inert, and biocompatible silico-tungsten oxide shell. The particles can be functionalized, optically detected, and optically manipulated. To show the functionalization the fluorescent dye NOPS was bound to the FePt core-shell nanoparticles with propyl-triethoxy-silane linkers and fluorescence of the labeled particles were observed in ethanol (EtOH). In aqueous dispersion the NOPS fluorescence is quenched making them invisible using 1-photon excitation. However, we observe bright luminescence of labeled and even unlabeled magnetic core-shell nanoparticles with multi-photon excitation. Luminescence can be detected in the near ultraviolet and the full visible spectral range by near infrared multi-photon excitation. For optical manipulation, we were able to drag clusters of particles, and maybe also single particles, by a focused laser beam that acts as optical tweezers by inducing an electric dipole in the insulated metal nanoparticles. In a first application, we show that the luminescence of the core-shell nanoparticles is bright enough for in vivo multi-photon imaging in the mouse neocortex down to cortical layer 5.

© 2014 Optical Society of America

OCIS Codes
(020.4180) Atomic and molecular physics : Multiphoton processes
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(300.6410) Spectroscopy : Spectroscopy, multiphoton
(160.4236) Materials : Nanomaterials

ToC Category:
Nanotechnology and Plasmonics

Original Manuscript: April 17, 2014
Revised Manuscript: June 20, 2014
Manuscript Accepted: June 23, 2014
Published: June 27, 2014

K.M. Seemann and B. Kuhn, "Multi-photon excited luminescence of magnetic FePt core-shell nanoparticles," Biomed. Opt. Express 5, 2446-2457 (2014)

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