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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 8 — Aug. 1, 2014
  • pp: 2614–2619

Direct observation and validation of fluorescein tear film break-up patterns by using a dual thermal-fluorescent imaging system

Tai-Yuan Su, Shu-Wen Chang, Chiao-Ju Yang, and Huihua Kenny Chiang  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 8, pp. 2614-2619 (2014)
http://dx.doi.org/10.1364/BOE.5.002614


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Abstract

The fluorescein tear film break-up test is a common tear film stability test for dry eye diagnosis. This test requires applying fluorescein sodium drops to a tear film to observe the tear film break-up. However, this test is limited by using the fluorescein sodium drops, which can induce reflex tearing and reduce the reliability of the diagnosis results. This paper proposes that tear film evaporation accelerates on the fluorescein tear film break-up area (FTBA), resulting in a lower temperature area (LTA) on the tear film. A dual modality system was established to capture the thermal and fluorescent image of fluorescein-stain tear films for 48 participants. Observations showed that the LTA and FTBA were highly correlated in their location (r = 0.82) and size (r = 0.91). This is first study to show that the FTBA and LTA are essentially the same region. This study demonstrated the feasibility of using the noncontact thermograph method to evaluate tear film stability without using a fluorescein sodium drop.

© 2014 Optical Society of America

OCIS Codes
(110.6820) Imaging systems : Thermal imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4470) Medical optics and biotechnology : Ophthalmology

ToC Category:
Ophthalmology Applications

History
Original Manuscript: May 9, 2014
Revised Manuscript: July 5, 2014
Manuscript Accepted: July 8, 2014
Published: July 14, 2014

Citation
Tai-Yuan Su, Shu-Wen Chang, Chiao-Ju Yang, and Huihua Kenny Chiang, "Direct observation and validation of fluorescein tear film break-up patterns by using a dual thermal-fluorescent imaging system," Biomed. Opt. Express 5, 2614-2619 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-8-2614


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