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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 8 — Aug. 1, 2014
  • pp: 2679–2685

In vivo quantitative photoacoustic microscopy of gold nanostar kinetics in mouse organs

Weitao Li, Xiaolian Sun, Yu Wang, Gang Niu, Xiaoyuan Chen, Zhiyu Qian, and Liming Nie  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 8, pp. 2679-2685 (2014)
http://dx.doi.org/10.1364/BOE.5.002679


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Abstract

We developed a high-resolution photoacoustic microscopy (PAM) system with a near-infrared (NIR) laser to noninvasively monitor the distribution of gold nanostar (GNS) in blood vessels, liver and spleen in mice. Photoacoustic images of organs at deep depths were continuously acquired in vivo every 30 minutes after a single dose of GNS by tail vein injection. The experimental results showed that GNS accumulated significantly in both liver and spleen from blood circulation after administration, which was qualitatively validated by fluorescence imaging. Our studies demonstrate that PAM might be potentially used for noninvasive tracing the kinetics of exogenous nanoparticles in biological system.

© 2014 Optical Society of America

OCIS Codes
(000.1430) General : Biology and medicine
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(180.0180) Microscopy : Microscopy
(110.5125) Imaging systems : Photoacoustics

ToC Category:
Photoacoustic Imaging and Spectroscopy

History
Original Manuscript: May 7, 2014
Revised Manuscript: June 3, 2014
Manuscript Accepted: July 11, 2014
Published: July 17, 2014

Citation
Weitao Li, Xiaolian Sun, Yu Wang, Gang Niu, Xiaoyuan Chen, Zhiyu Qian, and Liming Nie, "In vivo quantitative photoacoustic microscopy of gold nanostar kinetics in mouse organs," Biomed. Opt. Express 5, 2679-2685 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-8-2679


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