OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 8 — Aug. 1, 2014
  • pp: 2715–2725

Bone tissue phantoms for optical flowmeters at large interoptode spacing generated by 3D-stereolithography

Tiziano Binzoni, Alessandro Torricelli, Remo Giust, Bruno Sanguinetti, Paul Bernhard, and Lorenzo Spinelli  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 8, pp. 2715-2725 (2014)
http://dx.doi.org/10.1364/BOE.5.002715


View Full Text Article

Enhanced HTML    Acrobat PDF (1326 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

A bone tissue phantom prototype allowing to test, in general, optical flowmeters at large interoptode spacings, such as laser-Doppler flowmetry or diffuse correlation spectroscopy, has been developed by 3D-stereolithography technique. It has been demonstrated that complex tissue vascular systems of any geometrical shape can be conceived. Absorption coefficient, reduced scattering coefficient and refractive index of the optical phantom have been measured to ensure that the optical parameters reasonably reproduce real human bone tissue in vivo. An experimental demonstration of a possible use of the optical phantom, utilizing a laser-Doppler flowmeter, is also presented.

© 2014 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(280.2490) Remote sensing and sensors : Flow diagnostics

ToC Category:
Calibration, Validation and Phantom Studies

History
Original Manuscript: May 12, 2014
Revised Manuscript: June 30, 2014
Manuscript Accepted: July 12, 2014
Published: July 21, 2014

Citation
Tiziano Binzoni, Alessandro Torricelli, Remo Giust, Bruno Sanguinetti, Paul Bernhard, and Lorenzo Spinelli, "Bone tissue phantoms for optical flowmeters at large interoptode spacing generated by 3D-stereolithography," Biomed. Opt. Express 5, 2715-2725 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-8-2715


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. G. Soelkner, G. Mitic, and R. Lohwasser, “Monte Carlo simulations and laser Doppler flow measurements with high penetration depth in biological tissuelike head phantoms,” Appl. Opt.36, 5647–5654 (1997). [CrossRef] [PubMed]
  2. R. Lohwasser and G. Soelkner, “Experimental and theoretical laser-Doppler frequency spectra of a tissuelike model of a human head with capillaries,” Appl. Opt.38, 2128–2137 (1999). [CrossRef]
  3. R. G. M. Kolkman, E. Hondebrink, R. A. Bolt, W. Steenbergen, and F. F. M. de Mul, “Pulsed-laser doppler flowmetry provides basis for deep perfusion probing,” Rev. Sci. Instrum.72, 4242–4244 (2001). [CrossRef]
  4. T. Binzoni, T. S. Leung, D. Boggett, and D. Delpy, “Non-invasive laser Doppler perfusion measurements of large tissue volumes and human skeletal muscle blood RMS velocity,” Phys. Med. Biol.48, 2527–2549 (2003). [CrossRef] [PubMed]
  5. T. Binzoni and D. Van De Ville, “Noninvasive probing of the neurovascular system in human bone/bone marrow using near-infrared light,” J. Innov. Opt. Health Sci.04, 183–189 (2011). [CrossRef]
  6. M. Belau, M. Ninck, G. Hering, L. Spinelli, D. Contini, A. Torricelli, and T. Gisler, “Noninvasive observation of skeletal muscle contraction using near-infrared time-resolved reflectance and diffusing-wave spectroscopy,” J. Biomed. Opt.15, 057007 (2010). [CrossRef] [PubMed]
  7. G. Yu, T. Durduran, C. Zhou, R. Cheng, and A. G. Yodh, “Near-infrared diffuse correlation spectroscopy for assessment of tissue blood flow,” in Handbook of Biomedical Optics, D. A. Boas, C. Pitris, and N. Ramanujam, eds. (CRC: Boca Raton, 2011), pp. 195–216. [CrossRef]
  8. R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos. Trans. A Math. Phys. Eng. Sci.369, 4390–4406 (2011). [CrossRef] [PubMed]
  9. We consider here only non-invasive optical flowmeters working at large source/detector separation (i.e. ‘large interoptode spacing’; e.g. ≥ 1.5 cm), allowing measurements deep in the investigated tissues. Flowmeters at short interoptode spacing, working on extremely small volumes, are not considered here because they probably need another technical solution for the phantoms.
  10. T. Binzoni, D. Tchernin, J. Richiardi, D. Van De Ville, and J. N. Hyacinthe, “Haemodynamic responses to temperature changes of human skeletal muscle studied by laser-Doppler flowmetry,” Physiol. Meas.33, 1181–1197 (2012). [CrossRef] [PubMed]
  11. J. Näslund, J. Pettersson, T. Lundeberg, D. Linnarsson, and L. G. Lindberg, “Non-invasive continuous estimation of blood flow changes in human patellar bone,” Med. Biol. Eng. Comput.44, 501–509 (2006). [CrossRef] [PubMed]
  12. T. Binzoni, D. Tchernin, J. N. Hyacinthe, D. Van De Ville, and J. Richiardi, “Pulsatile blood flow in human bone assessed by laser-Doppler flowmetry and the interpretation of photoplethysmographic signals,” Physiol. Meas.34, 25–40 (2013). [CrossRef]
  13. F. Jaillon, S. E. Skipetrov, J. Li, G. Dietsche, G. Maret, and T. Gisler, “Diffusing-wave spectroscopy from headlike tissue phantoms: influence of a non-scattering layer,” Opt. Express.14, 10181–10194 (2006). [CrossRef] [PubMed]
  14. M. Brookes and W. Revell, Blood Supply of Bone: Scientific Aspects (Springer, 1998). [CrossRef]
  15. L. Spinelli, A. Rizzolo, M. Vanoli, M. Grassi, P. Eccher Zerbini, R. Pimentel, and A. Torricelli, “Optical properties of pulp and skin in brazilian mangoes in the 540–900 nm spectral range: implication for non-destructive maturity assessment by time-resolved reflectance spectroscopy,” (International Conference of Agricultural Engineering, CIGR-AgEng2012, Valencia (Spain), 2012).
  16. F. Martelli, S. Del Bianco, A. Ismaelli, and G. Zaccanti, Light propagation through biological tissue and other diffusive media: theory, solutions, and software ( SPIE,Washington2009).
  17. J. R. Mourant, T. Fuselier, J. Boyer, T. M. Johnson, and I. J. Bigio, “Predictions and measurements of scattering and absorption over broad wavelength ranges in tissue phantoms,” Appl. Opt.36, 949–957 (1997). [CrossRef] [PubMed]
  18. A. Pifferi, A. Torricelli, P. Taroni, A. Bassi, E. Chikoidze, E. Giambattistelli, and R. Cubeddu, “Optical biopsy of bone tissue: a step toward the diagnosis of bone pathologies,” J. Biomed. Opt.9, 474–480 (2004). [CrossRef] [PubMed]
  19. Y. Xu, N. Iftimia, H. Jiang, L. Key, and M. Bolster, “Imaging of in vitro and in vivo bones and joints with continuous-wave diffuse optical tomography,” Opt. Express8, 447–451 (2001). [CrossRef] [PubMed]
  20. P. Farzam, P. Zirak, T. Binzoni, and T. Durduran, “Pulsatile and steady-state hemodynamics of the human patella bone by diffuse optical spectroscopy,” Physiol. Meas.34, 839–857 (2013). [CrossRef] [PubMed]
  21. M. A. Bartlett and H. Jiang, “Effect of refractive index on the measurement of optical properties in turbid media,” Appl. Opt.40, 1735–1741 (2001). [CrossRef]
  22. R. Michels, F. Foschum, and A. Kienle, “Optical properties of fat emulsions,” Opt. Express16, 5907–5925 (2008). [CrossRef] [PubMed]
  23. F. C. Cheong, K. Xiao, and D. G. Grier, “Technical note: characterizing individual milk fat globules with holographic video microscopy,” J. Dairy Sci.92, 95–99 (2009). [CrossRef]
  24. P. B. Canham and A. C. Burton, “Distribution of size and shape in populations of normal human red cells,” Circ. Res.22, 405–422 (1968). [CrossRef] [PubMed]
  25. M. D. Waterworth, B. J. Tarte, A. J. Joblin, T. van Doorn, and H. E. Niesler, “Optical transmission properties of homogenised milk used as a phantom material in visible wavelength imaging,” Australas. Phys. Eng. Sci. Med.18, 39–44 (1995). [PubMed]
  26. R. Jensen, Handbook of Milk Composition, Food science and technology international series (Academic, 1995).
  27. H. Li, L. Lin, and S. Xie, “Refractive index of human whole blood with different types in the visible and near-infrared ranges,” (2000).
  28. T. Binzoni, T. S. Leung, M. L. Seghier, and D. T. Delpy, “Translational and Brownian motion in laser-Doppler flowmetry of large tissue volumes,” Phys. Med. Biol.49, 5445–5458 (2004). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited