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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 8 — Aug. 1, 2014
  • pp: 2837–2842

Study of freshly excised brain tissues using terahertz imaging

Seung Jae Oh, Sang-Hoon Kim, Young Bin Ji, Kiyoung Jeong, Yeonji Park, Jaemoon Yang, Dong Woo Park, Sam Kyu Noh, Seok-Gu Kang, Yong-Min Huh, Joo-Hiuk Son, and Jin-Suck Suh  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 8, pp. 2837-2842 (2014)
http://dx.doi.org/10.1364/BOE.5.002837


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Abstract

We demonstrated that tumors in freshly excised whole brain tissue could be differentiated clearly from normal brain tissue using a reflection-type terahertz (THz) imaging system. THz binary images of brain tissues with tumors indicated that the tumor boundaries in the THz images corresponded well to those in visible images. Grey and white-matter regions were distinguishable owing to the different distribution of myelin in the brain tissue. THz images corresponded closely with magnetic resonance imaging (MRI) results. The MRI and hematoxylin and eosin-stained microscopic images were investigated to account for the intensity differences in the THz images for fresh and paraffin-embedded brain tissue. Our results indicated that the THz signals corresponded to the cell density when water was removed. Thus, THz imaging could be used as a tool for label-free and real-time imaging of brain tumors, which would be helpful for physicians to determine tumor margins during brain surgery.

© 2014 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6795) Medical optics and biotechnology : Terahertz imaging

ToC Category:
Spectroscopic Diagnostics

History
Original Manuscript: May 20, 2014
Revised Manuscript: July 3, 2014
Manuscript Accepted: July 23, 2014
Published: July 29, 2014

Citation
Seung Jae Oh, Sang-Hoon Kim, Young Bin Ji, Kiyoung Jeong, Yeonji Park, Jaemoon Yang, Dong Woo Park, Sam Kyu Noh, Seok-Gu Kang, Yong-Min Huh, Joo-Hiuk Son, and Jin-Suck Suh, "Study of freshly excised brain tissues using terahertz imaging," Biomed. Opt. Express 5, 2837-2842 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-8-2837


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