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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 9 — Sep. 1, 2014
  • pp: 2978–2987

A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography

Hamid Pahlevaninezhad, Anthony M. D. Lee, Tawimas Shaipanich, Rashika Raizada, Lucas Cahill, Geoffrey Hohert, Victor X. D. Yang, Stephen Lam, Calum MacAulay, and Pierre Lane  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 9, pp. 2978-2987 (2014)
http://dx.doi.org/10.1364/BOE.5.002978


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Abstract

We present a power-efficient fiber-based imaging system capable of co-registered autofluorescence imaging and optical coherence tomography (AF/OCT). The system employs a custom fiber optic rotary joint (FORJ) with an embedded dichroic mirror to efficiently combine the OCT and AF pathways. This three-port wavelength multiplexing FORJ setup has a throughput of more than 83% for collected AF emission, significantly more efficient compared to previously reported fiber-based methods. A custom 900 µm diameter catheter ‒ consisting of a rotating lens assembly, double-clad fiber (DCF), and torque cable in a stationary plastic tube ‒ was fabricated to allow AF/OCT imaging of small airways in vivo. We demonstrate the performance of this system ex vivo in resected porcine airway specimens and in vivo in human on fingers, in the oral cavity, and in peripheral airways.

© 2014 Optical Society of America

OCIS Codes
(110.0110) Imaging systems : Imaging systems
(110.2350) Imaging systems : Fiber optics imaging
(110.4500) Imaging systems : Optical coherence tomography
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

ToC Category:
Endoscopes, Catheters and Micro-Optics

History
Original Manuscript: June 20, 2014
Revised Manuscript: July 31, 2014
Manuscript Accepted: August 1, 2014
Published: August 6, 2014

Citation
Hamid Pahlevaninezhad, Anthony M. D. Lee, Tawimas Shaipanich, Rashika Raizada, Lucas Cahill, Geoffrey Hohert, Victor X. D. Yang, Stephen Lam, Calum MacAulay, and Pierre Lane, "A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography," Biomed. Opt. Express 5, 2978-2987 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-9-2978


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