OSA's Digital Library

Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 9 — Sep. 1, 2014
  • pp: 3053–3058

A low-cost photoacoustic microscopy system with a laser diode excitation

Tianheng Wang, Sreyankar Nandy, Hassan S. Salehi, Patrick D. Kumavor, and Quing Zhu  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 9, pp. 3053-3058 (2014)
http://dx.doi.org/10.1364/BOE.5.003053


View Full Text Article

Enhanced HTML    Acrobat PDF (1150 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Photoacoustic microscopy (PAM) is capable of mapping microvasculature networks in biological tissue and has demonstrated great potential for biomedical applications. However, the clinical application of the PAM system is limited due to the use of bulky and expensive pulsed laser sources. In this paper, a low-cost optical-resolution PAM system with a pulsed laser diode excitation has been introduced. The lateral resolution of this PAM system was estimated to be 7 µm by imaging a carbon fiber. The phantoms made of polyethylene tubes filled with blood and a mouse ear were imaged to demonstrate the feasibility of this PAM system for imaging biological tissues.

© 2014 Optical Society of America

OCIS Codes
(110.5120) Imaging systems : Photoacoustic imaging
(140.2020) Lasers and laser optics : Diode lasers
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Photoacoustic Imaging and Spectroscopy

History
Original Manuscript: June 10, 2014
Revised Manuscript: July 25, 2014
Manuscript Accepted: August 8, 2014
Published: August 14, 2014

Citation
Tianheng Wang, Sreyankar Nandy, Hassan S. Salehi, Patrick D. Kumavor, and Quing Zhu, "A low-cost photoacoustic microscopy system with a laser diode excitation," Biomed. Opt. Express 5, 3053-3058 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-9-3053


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum.77(4), 041101 (2006). [CrossRef]
  2. L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012). [CrossRef] [PubMed]
  3. P. Beard, “Biomedical photoacoustic imaging,” Interface Focus1(4), 602–631 (2011). [CrossRef] [PubMed]
  4. A. Karabutov, E. V. Savateeva, N. B. Podymova, and A. A. Oraevsky, “Backward mode detection of laser-induced wide-band ultrasonic transients with optoacoustic transducer,” J. Appl. Phys.87(4), 2003–2014 (2000). [CrossRef]
  5. X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003). [CrossRef] [PubMed]
  6. T. Wang, P. D. Kumavor, and Q. Zhu, “Application of laser pulse stretching scheme for efficiently delivering laser energy in photoacoustic imaging,” J. Biomed. Opt.17(6), 061218 (2012). [CrossRef] [PubMed]
  7. J. Yao and L. V. Wang, “Photoacoustic microscopy,” Laser Photon. Rev.7(5), 758–778 (2013). [CrossRef] [PubMed]
  8. S. Hu and L. V. Wang, “Optical-resolution photoacoustic microscopy: auscultation of biological systems at the cellular level,” Biophys. J.105(4), 841–847 (2013). [CrossRef] [PubMed]
  9. H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol.24(7), 848–851 (2006). [CrossRef] [PubMed]
  10. K. Maslov, H. F. Zhang, S. Hu, and L. V. Wang, “Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries,” Opt. Lett.33(9), 929–931 (2008). [CrossRef] [PubMed]
  11. R. J. Zemp, L. Song, R. Bitton, K. K. Shung, and L. V. Wang, “Realtime photoacoustic microscopy in vivo with a 30-MHz ultrasound array transducer,” Opt. Express16(11), 7915–7928 (2008). [CrossRef] [PubMed]
  12. L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics3(9), 503–509 (2009). [CrossRef] [PubMed]
  13. B. Rao, L. Li, K. Maslov, and L. V. Wang, “Hybrid-scanning optical-resolution photoacoustic microscopy for in vivo vasculature imaging,” Opt. Lett.35(10), 1521–1523 (2010). [CrossRef] [PubMed]
  14. S. Hu, K. Maslov, and L. V. Wang, “Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed,” Opt. Lett.36(7), 1134–1136 (2011). [CrossRef] [PubMed]
  15. L. Wang, K. Maslov, J. Yao, B. Rao, and L. V. Wang, “Fast voice-coil scanning optical-resolution photoacoustic microscopy,” Opt. Lett.36(2), 139–141 (2011). [CrossRef] [PubMed]
  16. P. Hajireza, W. Shi, and R. J. Zemp, “Real-time handheld optical-resolution photoacoustic microscopy,” Opt. Express19(21), 20097–20102 (2011). [CrossRef] [PubMed]
  17. C. Zhang, K. Maslov, S. Hu, R. Chen, Q. Zhou, K. K. Shung, and L. V. Wang, “Reflection-mode submicron-resolution in vivo photoacoustic microscopy,” J. Biomed. Opt.17(2), 020501 (2012). [CrossRef] [PubMed]
  18. Z. Guo, C. Favazza, A. Garcia-Uribe, and L. V. Wang, “Quantitative photoacoustic microscopy of optical absorption coefficients from acoustic spectra in the optical diffusive regime,” J. Biomed. Opt.17(6), 066011 (2012). [CrossRef] [PubMed]
  19. S. L. Chen, Z. Xie, T. Ling, L. J. Guo, X. Wei, and X. Wang, “Miniaturized all-optical photoacoustic microscopy based on microelectromechanical systems mirror scanning,” Opt. Lett.37(20), 4263–4265 (2012). [CrossRef] [PubMed]
  20. X. Zhang, H. F. Zhang, and S. Jiao, “Optical coherence photoacoustic microscopy: accomplishing optical coherence tomography and photoacoustic microscopy with a single light source,” J. Biomed. Opt.17(3), 030502 (2012). [CrossRef] [PubMed]
  21. J. Yao, L. Wang, C. Li, C. Zhang, and L. V. Wang, “Photoimprint photoacoustic microscopy for three-dimensional label-free subdiffraction imaging,” Phys. Rev. Lett.112(1), 014302 (2014). [CrossRef] [PubMed]
  22. Z. Xie, W. Roberts, P. Carson, X. Liu, C. Tao, and X. Wang, “Evaluation of bladder microvasculature with high-resolution photoacoustic imaging,” Opt. Lett.36(24), 4815–4817 (2011). [CrossRef] [PubMed]
  23. T. Wang, Y. Yang, U. Alqasemi, P. D. Kumavor, X. Wang, M. Sanders, M. Brewer, and Q. Zhu, “Characterization of ovarian tissue based on quantitative analysis of photoacoustic microscopy images,” Biomed. Opt. Express4(12), 2763–2768 (2013). [CrossRef] [PubMed]
  24. T. J. Allen and P. C. Beard, “Pulsed near-infrared laser diode excitation system for biomedical photoacoustic imaging,” Opt. Lett.31(23), 3462–3464 (2006). [CrossRef] [PubMed]
  25. R. G. M. Kolkman, W. Steenbergen, and T. G. van Leeuwen, “In vivo photoacoustic imaging of blood vessels with a pulsed laser diode,” Lasers Med. Sci.21(3), 134–139 (2006). [CrossRef] [PubMed]
  26. K. Maslov and L. V. Wang, “Photoacoustic imaging of biological tissue with intensity-modulated continuous-wave laser,” J. Biomed. Opt.13(2), 024006 (2008). [CrossRef] [PubMed]
  27. L. Zeng, G. Liu, D. Yang, and X. Ji, “3D-visual laser-diode-based photoacoustic imaging,” Opt. Express20(2), 1237–1246 (2012). [CrossRef] [PubMed]
  28. P. LeBoulluec, H. Liu, and B. Yuan, “A cost-efficient frequency-domain photoacoustic imaging system,” Am. J. Phys.81(9), 712–717 (2013). [CrossRef] [PubMed]
  29. L. Zeng, G. Liu, D. Yang, and X. Ji, “Portable optical-resolution photoacoustic microscopy with a pulsed laser diode excitation,” Appl. Phys. Lett.102(5), 053704 (2013). [CrossRef]
  30. A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. Sanders, M. Brewer, and Q. Zhu, “Co-registered 3-D ultrasound and photoacoustic imaging system for ovarian tissue characterization,” J. Biomed. Opt.14(5), 054014 (2009).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1 Fig. 2 Fig. 3
 
Fig. 4 Fig. 5
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited