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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 9 — Sep. 1, 2014
  • pp: 3074–3079

Design of miniaturized illumination for transvaginal co-registered photoacoustic and ultrasound imaging

Hassan S. Salehi, Tianheng Wang, Patrick D. Kumavor, Hai Li, and Quing Zhu  »View Author Affiliations

Biomedical Optics Express, Vol. 5, Issue 9, pp. 3074-3079 (2014)

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A novel lens-array based illumination design for a compact co-registered photoacoustic/ultrasound transvaginal probe has been demonstrated. The lens array consists of four cylindrical lenses that couple the laser beams into four 1-mm-core multi-mode optical fibers with optical coupling efficiency of ~87%. The feasibility of our lens array was investigated by simulating the lenses and laser beam profiles using Zemax. The laser fluence on the tissue surface was experimentally measured and was below the American National Standards Institute (ANSI) safety limit. Spatial distribution of hemoglobin oxygen saturation (sO2) of a mouse tumor was obtained in vivo using photoacoustic measurements at multiple wavelengths. Furthermore, benign and malignant ovaries were imaged ex vivo and evaluated histologically. The co-registered images clearly showed different patterns of blood vasculature. These results highlight the clinical potential of our system for noninvasive photoacoustic and ultrasound imaging of ovarian tissue and cancer detection and diagnosis.

© 2014 Optical Society of America

OCIS Codes
(110.0110) Imaging systems : Imaging systems
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(170.6960) Medical optics and biotechnology : Tomography
(170.7170) Medical optics and biotechnology : Ultrasound
(170.2945) Medical optics and biotechnology : Illumination design

ToC Category:
Multimodal Imaging

Original Manuscript: June 16, 2014
Revised Manuscript: July 29, 2014
Manuscript Accepted: August 11, 2014
Published: August 19, 2014

Virtual Issues
Topics in Biomedical Optics from OSA's BIOMED 2014 Conference (2014) Biomedical Optics Express

Hassan S. Salehi, Tianheng Wang, Patrick D. Kumavor, Hai Li, and Quing Zhu, "Design of miniaturized illumination for transvaginal co-registered photoacoustic and ultrasound imaging," Biomed. Opt. Express 5, 3074-3079 (2014)

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