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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 9 — Sep. 1, 2014
  • pp: 3140–3149

Preparation of a skin equivalent phantom with interior micron-scale vessel structures for optical imaging experiments

Chen Chen, Florian Klämpfl, Christian Knipfer, Max Riemann, Rajesh Kanawade, Florian Stelzle, and Michael Schmidt  »View Author Affiliations


Biomedical Optics Express, Vol. 5, Issue 9, pp. 3140-3149 (2014)
http://dx.doi.org/10.1364/BOE.5.003140


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Abstract

A popular alternative of preparing multilayer or microfluidic chip based phantoms could have helped to simulate the subsurface vascular network, but brought inevitable problems. In this work, we describe the preparation method of a single layer skin equivalent tissue phantom containing interior vessel channels, which mimick the superficial microvascular structure. The fabrication method does not disturb the optical properties of the turbiding matrix material. The diameter of the channels reaches a value of 50 μm. The size, as well as the geometry of the generated vessel structures are investigated by using the SD-OCT system. Our preliminary results confirm that fabrication of such a phantom is achievable and reproducible. Prospectively, this phantom is used to calibrate the optical angiographic imaging approaches.

© 2014 Optical Society of America

OCIS Codes
(110.7050) Imaging systems : Turbid media
(160.4760) Materials : Optical properties
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(350.0350) Other areas of optics : Other areas of optics

ToC Category:
Calibration, Validation and Phantom Studies

History
Original Manuscript: June 25, 2014
Revised Manuscript: August 10, 2014
Manuscript Accepted: August 15, 2014
Published: August 22, 2014

Citation
Chen Chen, Florian Klämpfl, Christian Knipfer, Max Riemann, Rajesh Kanawade, Florian Stelzle, and Michael Schmidt, "Preparation of a skin equivalent phantom with interior micron-scale vessel structures for optical imaging experiments," Biomed. Opt. Express 5, 3140-3149 (2014)
http://www.opticsinfobase.org/boe/abstract.cfm?URI=boe-5-9-3140


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