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Biomedical Optics Express

Biomedical Optics Express

  • Editor: Joseph A. Izatt
  • Vol. 5, Iss. 9 — Sep. 1, 2014
  • pp: 3217–3230

Optical coherence Doppler tomography for quantitative cerebral blood flow imaging

Jiang You, Congwu Du, Nora D. Volkow, and Yingtian Pan  »View Author Affiliations

Biomedical Optics Express, Vol. 5, Issue 9, pp. 3217-3230 (2014)

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Optical coherence Doppler tomography (ODT) is a promising neurotechnique that permits 3D imaging of the cerebral blood flow (CBF) network; however, quantitative CBF velocity (CBFv) imaging remains challenging. Here we present a simple phase summation method to enhance slow capillary flow detection sensitivity without sacrificing dynamic range for fast flow and vessel tracking to improve angle correction for absolute CBFv quantification. Flow phantom validation indicated that the CBFv quantification accuracy increased from 15% to 91% and the coefficient of variation (CV) decreased 9.3-fold; in vivo mouse brain validation showed that CV decreased 4.4-/10.8- fold for venular/arteriolar flows. ODT was able to identify cocaine-elicited microischemia and quantify CBFv disruption in branch vessels and capillaries that otherwise would have not been possible.

© 2014 Optical Society of America

OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(280.2490) Remote sensing and sensors : Flow diagnostics

ToC Category:
Optical Coherence Tomography

Original Manuscript: June 24, 2014
Revised Manuscript: July 28, 2014
Manuscript Accepted: August 4, 2014
Published: August 28, 2014

Virtual Issues
Topics in Biomedical Optics from OSA's BIOMED 2014 Conference (2014) Biomedical Optics Express

Jiang You, Congwu Du, Nora D. Volkow, and Yingtian Pan, "Optical coherence Doppler tomography for quantitative cerebral blood flow imaging," Biomed. Opt. Express 5, 3217-3230 (2014)

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