OSA's Digital Library

Chinese Optics Letters

Chinese Optics Letters

| PUBLISHED MONTHLY BY CHINESE LASER PRESS AND DISTRIBUTED BY OSA

  • Vol. 2, Iss. 7 — Jul. 10, 2004
  • pp: 411–413

Application of transcutaneous diffuse reflectance spectroscopy in the measurement of blood glucose concentration

Wenliang Chen, Rong Liu, Houxin Cui, Kexin Xu, and Lina Lv  »View Author Affiliations


Chinese Optics Letters, Vol. 2, Issue 7, pp. 411-413 (2004)


View Full Text Article

Acrobat PDF (482 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations
  • Export Citation/Save Click for help

Abstract

In this paper, the propagation characteristics of near-infrared (NIR) light in the palm tissue are analyzed, and the principle and feasibility of using transcutaneous diffuse reflectance spectroscopy for non-invasive blood glucose detection are presented. An optical probe suitable for measuring the diffuse reflectance spectrum of human palm and a non-invasive blood glucose detection system using NIR spectroscopy are designed. Based on this system, oral glucose tolerance tests are performed to measure the blood glucose concentrations of two young healthy volunteers. The partial least square calibration model is then constructed by all individual experimental data. The final result shows that correlation coefficients of the two experiments between the predicted blood glucose concentrations and the reference blood glucose concentrations are 0.9870 and 0.9854, respectively. The root mean square errors of prediction of full cross validation are 0.54 and 0.52 mmol/l, respectively.

© 2005 Chinese Optics Letters

OCIS Codes
(250.0250) Optoelectronics : Optoelectronics
(300.0300) Spectroscopy : Spectroscopy

Citation
Wenliang Chen, Rong Liu, Houxin Cui, Kexin Xu, and Lina Lv, "Application of transcutaneous diffuse reflectance spectroscopy in the measurement of blood glucose concentration," Chin. Opt. Lett. 2, 411-413 (2004)
http://www.opticsinfobase.org/col/abstract.cfm?URI=col-2-7-411


Sort:  Author  |  Year  |  Journal  |  Reset

References

  1. O. S. Khalil, Clinical Chem. 45, 165 (1999).
  2. Dahne, Claus, Gross, and Daniel, Spectrophotometric method and apparatus for the non-invasive determination of glucose in body tissues US patent 4655225 (April 7, 1987).
  3. S. F. Malin, T. L. Ruchti, T. B. Blank, S. N. Thennadil, and S. L. Monfre, Clinical Chem. 45, 1651 (1999).
  4. J. Tenhunen, H. Kopola, and R. Myllyla, Measurement 24, 173 (1998).
  5. K. Maruo, M. Tsurugi, J. Chin, T. Ota, H. Arimoto, Y. Yamada, M. Tamura, M. Ishii, and Y. Ozaki, IEEE J. Sel. Top. Quantum Electron. 9, 322 (2003).
  6. K. X. Xu, W. L. Chen, J. Y. Jiang, and Q. J. Qiu, Proc. SPIE 5330, 83 (2004).
  7. M. A. Arnold, G. W. Small, D. Xiang, J. Qui, and D. W. Murhammer, Anal. Chem. 76, 2583 (2004).
  8. I. V. Meglinski and S. J. Matcher, Physiol. Meas. 23, 741 (2002).
  9. W. L. Chen, R. Liu, H. X. Cui, and K. X. Xu, J. Optoelectron. Laser (in Chinese) 15, 242 (2004).
  10. T. L. Troy and S. N. Thennadil, J. Biomed. Opt. 6, 167 (2001).

Cited By

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited