The aim of this study is to further measure the effect of 632.8-nm helium-neon laser on fast excitatory postsynaptic potential (f-EPSP) of postganglionic neurons in isolated rat superior cervical ganglia by means of intracellular recording techniques. The neurons with f-EPSP were irradiated by different power densities (1-5 mW/cm2) laser. Irradiated by the 2-mW/cm2 laser, the amplitude of the f-EPSP could augment (P<0.05, paired t test) and even cause action potential at the end of the first 1-2 minutes, the f-EPSP could descend and last for 3-8 minutes. But the amplitude of the f-EPSP of neurons irradiated by the 5-mW/cm2 laser could depress for the irradiating periods. The results show that: 1) the variation of the amplitude of f-EPSP caused by laser is power density-dependent and time-dependent; 2) there exist the second-order phases in the interaction of the helium-neon laser with neurons. These findings may provide certain evidence in explanation of the mechanisms of clinical helium-neon laser therapy.
© 2005 Chinese Optics Letters
(140.0140) Lasers and laser optics : Lasers and laser optics
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(330.5370) Vision, color, and visual optics : Physiological optics
Hua Mo, Ping He, and Ning Mo, "Effect of helium-neon laser on fast excitatory postsynaptic potential of neurons in the isolated rat superior cervical ganglia," Chin. Opt. Lett. 2, 477-479 (2004)